Web of Science: 0 cites, Scopus: 1 cites, Google Scholar: cites,
Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome : baseline cross-sectional analysis of the PREDIMED-plus study
Mallorquí Bagué, Núria (Hospital de Bellvitge)
Lozano-Madrid, María (Hospital Universitari de Bellvitge)
Toledo, Estefanía (Instituto de Salud Carlos III)
Corella, Dolores (Universidad de Valencia. Departamento de Medicina Preventiva y Salud Pública)
Salas-Salvadó, Jordi (Instituto de Salud Carlos III)
Cuenca-Royo, Aida (Institut Hospital del Mar d'Investigacions Mèdiques)
Vioque, Jesús (Universidad Miguel Hernández. Departamento de Salud Pública)
Romaguera, Dora (Instituto de Salud Carlos III)
Martínez, J. Alfredo (Instituto de Salud Carlos III)
Wärnberg, Julia (Universidad de Málaga)
López-Miranda, José (Instituto de Salud Carlos III)
Estruch, Ramon (Hospital Clínic i Provincial de Barcelona)
Bueno-Cavanillas, Aurora (Instituto de Salud Carlos III)
Alonso-Gómez, Ángel (Instituto de Salud Carlos III)
Tur, Josep A. (Instituto de Salud Carlos III)
Tinahones, Francisco J. (Instituto de Salud Carlos III)
Serra Majem, Lluís (Instituto de Salud Carlos III)
Martín, Vicente (Instituto de Salud Carlos III)
Lapetra, José (Instituto de Salud Carlos III)
Vázquez, Clotilde (Instituto de Salud Carlos III)
Pintó, Xavier (Instituto de Salud Carlos III)
Vidal, Josep (Hospital Clínic i Provincial de Barcelona)
Daimiel, Lidia (Universidad CEU San Pablo)
Gaforio Martínez, José Juan (Universidad de Jaén)
Matía Martín, Pilar (Hospital Clínico San Carlos (Madrid))
Ros, Emilio (Instituto de Salud Carlos III)
Granero, Roser (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Buil-Cosiales, Pilar (Instituto de Salud Carlos III)
Barragán, Rocío (Universidad de Valencia. Departamento de Medicina Preventiva y Salud Pública)
Bulló, Mònica (Instituto de Salud Carlos III)
Castañer, Olga (Instituto de Salud Carlos III)
García-de-la-Hera, Manoli (Universidad Miguel Hernández de Elche)
Yañez Juan, Aina (Universitat de les Illes Balears)
Abete, Itziar (Instituto de Salud Carlos III)
García-Ríos, Antonio (Instituto de Salud Carlos III)
Ruiz-Canela, Miguel (Instituto de Salud Carlos III)
Díaz-López, Andrés (Instituto de Salud Carlos III)
Jiménez-Murcia, Susana (Hospital Universitari de Bellvitge (IBIDELL))
Martínez-González, Miguel A. (Instituto de Salud Carlos III)
de la Torre, Rafael (Instituto de Salud Carlos III)
Fernández Aranda, Fernando (Hospital Universitari de Bellvitge)

Data: 2018
Resum: This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53 mmol/mol displayed better cognitive performance when compared to those with HbA1c≥53 mmol/mol. Our results provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Publicat a: Scientific reports, Vol. 8 (October 2018) , art. 16128, ISSN 2045-2322

DOI: 10.1038/s41598-018-33843-8
PMID: 30382190


9 p, 1.4 MB

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 Registre creat el 2019-06-18, darrera modificació el 2019-07-15



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