Web of Science: 9 citations, Scopus: 8 citations, Google Scholar: citations,
Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
Sardanyés, Josep (Universitat Pompeu Fabra)
Simó, Carles (Universitat de Barcelona. Departament de Matemàtica Aplicada i Anàlisi)
Martínez Barchino, Regina (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
Solé, Ricard V. (Universitat Pompeu Fabra)
Elena, Santiago F. (Universitat Politècnica de València. Instituto de Biología Molecular y Celular de Plantas)

Date: 2014
Abstract: The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a phenotypic version of the classic Eigen's model that incorporates beneficial, neutral, deleterious, and lethal mutations. By parameterizing the model with available experimental data on the DMFE of Vesicular stomatitis virus (VSV) and Tobacco etch virus (TEV), we found that increasing mutation does not totally push the entire viral quasispecies towards deleterious or lethal regions of the phenotypic sequence space. The probability of finding regions in the parameter space of the general model that results in a quasispecies only composed by lethal phenotypes is extremely small at equilibrium and in transient times. The implications of our findings can be extended to other scenarios, such as lethal mutagenesis or genomically unstable cancer, where increased mutagenesis has been suggested as a potential therapy.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Published in: Scientific reports (Nature Publishing Group), Vol. 4 (2014) , art. 4625, ISSN 2045-2322

DOI: 10.1038/srep04625
PMID: 24713667

11 p, 854.8 KB

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Articles > Research articles
Articles > Published articles

 Record created 2019-06-20, last modified 2021-01-18

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