Flexible graphene transistors for recording cell action potentials
Blaschke, Benno M. (Technische Universität München. Walter Schottky Institut. Physik-Department)
Lottner, Martin (Technische Universität München. Walter Schottky Institut. Physik-Department)
Drieschner, Simon (Technische Universität München. Walter Schottky Institut. Physik-Department)
Bonaccini Calia, Andrea (Institut Català de Nanociència i Nanotecnologia)
Stoiber, Karolina (Technische Universität München. Walter Schottky Institut. Physik-Department)
Rousseau, Lionel (University Paris EST. École Supérieure d'Ingénieurs en Électrotechnique et Électronique)
Lissourges, Gaëlle (University Paris EST. École Supérieure d'Ingénieurs en Électrotechnique et Électronique)
Garrido, Jose (Institut Català de Nanociència i Nanotecnologia)

Fecha:	2016
Resumen:	Graphene solution-gated field-effect transistors (SGFETs) are a promising platform for the recording of cell action potentials due to the intrinsic high signal amplification of graphene transistors. In addition, graphene technology fulfills important key requirements for in-vivo applications, such as biocompability, mechanical flexibility, as well as ease of high density integration. In this paper we demonstrate the fabrication of flexible arrays of graphene SGFETs on polyimide, a biocompatible polymeric substrate. We investigate the transistor's transconductance and intrinsic electronic noise which are key parameters for the device sensitivity, confirming that the obtained values are comparable to those of rigid graphene SGFETs. Furthermore, we show that the devices do not degrade during repeated bending and the transconductance, governed by the electronic properties of graphene, is unaffected by bending. After cell culture, we demonstrate the recording of cell action potentials from cardiomyocyte-like cells with a high signal-to-noise ratio that is higher or comparable to competing state of the art technologies. Our results highlight the great capabilities of flexible graphene SGFETs in bioelectronics, providing a solid foundation for in-vivo experiments and, eventually, for graphene-based neuroprosthetics.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió acceptada per publicar
Materia:	Bioelectronics ; Biosensors ; Flexible electronics ; Graphene
Publicado en:	2D materials, Vol. 3, issue 2 (June 2016) , art. 25007, ISSN 2053-1583

DOI: 10.1088/2053-1583/3/2/025007

Postprint 12 p, 8.3 MB

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