Deciphering hIAPP : a novel way to cure diabetes
Ruiz López, Iñigo
Pallarès i Goitiz, Irantzu, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Universitat Autònoma de Barcelona.
Facultat de Biociències
Date: |
2019-05-29 |
Abstract: |
Human islet amyloid polypeptide (hIAPP) is produced by pancreatic β-cells and is involved in type-II diabetes mellitus (T2DM) pathogenesis. In T2DM, the loss of pancreatic β-cell mass is accompanied by the accumulation of amyloid deposits of hIAPP. The relationship between amyloidosis, cell-death and disease progression is extremely complex. My work discusses the evidence supporting the role of oligomers as drivers of toxicity, suggests a model to understand IAPP interaction with membranes and proposes unexplored therapeutic approaches. |
Rights: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
Language: |
Anglès |
Studies: |
Biotecnologia [2500253] |
Study plan: |
Grau en Biotecnologia [815] |
Document: |
Treball final de grau |
Subject: |
Hiapp ;
T2DM ;
Beta-cells ;
Diabetes ;
Oligomers ;
Membrane ;
Membrane-disruption ;
Amyloid ;
Aggregation ;
Therapy ;
Protein misfolding disease |
The record appears in these collections:
Research literature >
Bachelor's degree final project >
Biosciences Faculty
Record created 2019-08-27, last modified 2024-05-18