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Machine learning to understand the immune-inflammatory pathways in fibromyalgia
Andrés-Rodríguez, Laura (Universitat Autònoma de Barcelona)
Borràs i Hernández, Francesc Xavier (Universitat Autònoma de Barcelona)
Feliu Soler, Albert (Universitat Autònoma de Barcelona)
Pérez-Aranda, Adrián (Parc Sanitari Sant Joan de Déu)
Rozadilla-Sacanell, Antoni (Parc Sanitari Sant Joan de Déu)
Arranz, Belén (Parc Sanitari Sant Joan de Déu)
Montero-Marín, Jesús (RedIAPP (Red de Investigación en Actividades Preventivas y Promoción de la Salud))
García-Campayo, Javier (RedIAPP (Red de Investigación en Actividades Preventivas y Promoción de la Salud))
Angarita Osorio, Natalia (Parc Sanitari Sant Joan de Déu)
Maes, Michael (Chulalongkorn University)
Luciano, Juan V. (Parc Sanitari Sant Joan de Déu)

Date: 2019
Abstract: Fibromyalgia (FM) is a chronic syndrome characterized by widespread musculoskeletal pain, and physical and emotional symptoms. Although its pathophysiology is largely unknown, immune-inflammatory pathways may be involved. We examined serum interleukin (IL)-6, high sensitivity C-reactive protein (hs-CRP), CXCL-8, and IL-10 in 67 female FM patients and 35 healthy women while adjusting for age, body mass index (BMI), and comorbid disorders. We scored the Fibromyalgia Severity Score, Widespread Pain Index (WPI), Symptom Severity Scale (SSS), Hospital Anxiety (HADS-A), and Depression Scale and the Perceived Stress Scale (PSS-10). Clinical rating scales were significantly higher in FM patients than in controls. After adjusting for covariates, IL-6, IL-10, and CXCL-8 were lower in FM than in HC, whereas hs-CRP did not show any difference. Binary regression analyses showed that the diagnosis FM was associated with lowered IL-10, quality of sleep, aerobic activities, and increased HADS-A and comorbidities. Neural networks showed that WPI was best predicted by quality of sleep, PSS-10, HADS-A, and the cytokines, while SSS was best predicted by PSS-10, HADS-A, and IL-10. Lowered levels of cytokines are associated with FM independently from confounders. Lowered IL-6 and IL-10 signaling may play a role in the pathophysiology of FM.
Note: Número d'acord de subvenció ISCIII/RD16/0007/0005
Note: Número d'acord de subvenció ISCIII/RD16/0007/0012
Note: Número d'acord de subvenció ISCIII/CD16/00147
Note: Número d'acord de subvenció ISCIII/CP14/00087
Note: Número d'acord de subvenció AGAUR/2017/FI_B00754
Note: Número d'acord de subvenció AGAUR/2018/FI_B00783
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Fibromyalgia ; Widespread pain ; Cytokines ; Inflammation ; Neuro-immune
Published in: International Journal of Molecular Sciences, Vol. 20, núm. 17 (2019) , p. 4231, ISSN 1422-0067

Adreça original:
DOI: 10.3390/ijms20174231
PMID: 31470635

16 p, 641.2 KB

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Articles > Research articles
Articles > Published articles

 Record created 2019-09-02, last modified 2019-10-07

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