Web of Science: 2 citations, Scopus: 2 citations, Google Scholar: citations
Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease
Carvajal, Silvia (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Perramón, Meritxell (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Oró, Denise (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Casals, Eudald (Wuyi University. School of Biotechnology and Health Sciences)
Fernández Varo, Guillermo (Universitat de Barcelona. Departament de Biomedicina)
Parra-Robert, Marina (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
González de la Presa, Bernardino. (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Ribera, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Pastor, Óscar (Hospital Universitario Ramón y Cajal. Servicio de Bioquímica Clínica)
Morales Ruiz, Manuel (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Jiménez, Wladimiro (Universitat de Barcelona. Departament de Biomedicina)

Date: 2019
Abstract: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium oxide nanoparticles (CeO₂NPs) have emerged as a new antioxidant agent with hepatoprotective properties in experimental liver disease. The aim of the current investigation was to elucidate whether CeO₂NPs display beneficial effects in an experimental model of NAFLD. Therefore, fifteen Wistar rats were subjected to a methionine and choline deficient diet (MCDD) for 6 weeks and intravenously treated with CeO₂NPs or vehicle during the weeks three and four of the diet. The effect of CeO₂NPs on serum biochemistry, hepatic steatosis, inflammation, fatty acid content and expression of reactive oxygen species (ROS) and lipid metabolism related genes was assessed. MCDD fed rats showed increased inflammation, enhanced hepatic lipid accumulation of both saturated and unsaturated fatty acids (FAs) and overexpression of genes related to fatty liver and ROS metabolism. Treatment with CeONPs was able to reduce the size and content of hepatocyte lipid droplets, the hepatic concentration of triglyceride- and cholesterol ester-derived FAs and the expression of several genes involved in cytokine, adipokine and chemokine signaling pathways. These findings suggest that CeO₂NPs could be of beneficial value in NAFLD.
Note: Número d'acord de subvenció MICINN/SAFRTI2018-094734-B-C21
Note: Número d'acord de subvenció MICINN/SAF2016-75358-R
Note: Número d'acord de subvenció MINECO/P74844I/15/00777
Note: Número d'acord de subvenció MINECO/SAF2015-64126R
Note: Número d'acord de subvenció MINECO/BES-2013-063685
Note: Número d'acord de subvenció AGAUR/2014/SGR-219
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Biologics ; Nanoparticles ; Non-alcoholic fatty liver disease
Published in: Scientific reports, Vol. 9 (2019) , art. 12848, ISSN 2045-2322

DOI: 10.1038/s41598-019-49262-2
PMID: 31492960


20 p, 2.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles

 Record created 2019-11-19, last modified 2020-01-13



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