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Chiral recognition by dissolution dynamic nuclear polarization NMR spectroscopy
Monteagudo Soldevilla, Eva (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear)
Virgili, Albert (Universitat Autònoma de Barcelona. Departament de Química)
Parella Coll, Teodor (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear)
Pérez-Trujillo, Míriam (Universitat Autònoma de Barcelona. Departament de Química)

Data: 2018
Resum: The recognition of enantiomeric molecules by chemical analytical techniques is still a challenge. A method based on d-DNP (dissolution dynamic nuclear polarization) NMR spectroscopy to study chiral recognition was described for the first time [1]. DNP allows NMR sensitivity to be boosted by several orders of magnitude, overcoming one of the main limitations of NMR spectroscopy [2]. A method integrating d-DNP and 13C-NMR-aided enantiodifferentiation using chiral solvating agents (CSA) was developed, in which only the chiral analyte was hyperpolarized and selectively observed by NMR. The described method enhances the sensitivity of the conventional NMR-based procedure [3] and lightens the common problem of signal overlapping between analyte and CSA. As proof of concept, racemic metabolite 13C-labeled DL-methionine was enantiodifferentiated by a single-scan 13C-NMR experiment. This method entails a step forward in the chiral recognition of small molecules by NMR spectroscopy; it opens new possibilities in situations where the sensitivity is limited, for example, when low analyte concentration is available or when measurement of an insensitive nucleus is required. The advantages and current limitations of the method, as well as future perspectives, are discussed.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Publicat a: Proceedings, Vol. 2 (2018) , p. 1, ISSN 2504-3900

DOI: 10.3390/proceedings2010066


1 p, 142.0 KB

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