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Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)
Zeljenková, Dagmar (Slovak Medical University)
Ambrušová, Katarína (Slovak Medical University)
Bartušová, Mária (Slovak Medical University)
Kebis, Anton (Slovak Medical University)
Kovrižnych, Jevgenij (Slovak Medical University)
Krivošíková, Miroslava (Slovak Medical University)
Líšková, Aurélia (Slovak Medical University)
Rollerová, Eva (Slovak Medical University)
Spustová, Viera (Slovak Medical University)
Szabová, Elena (Slovak Medical University)
Tulinská, Jana (Slovak Medical University)
Wimmerová, Sona (Slovak Medical University)
Levkut, Mikuláš (TOPALAB)
Révajová, Viera (TOPALAB)
Ševčíková, Zuzana (TOPALAB)
Schmidt, Kerstin (BioMath GmbH)
Schmidtke, Jörg (BioMath GmbH)
La Paz, Jose Luis (Centre de Recerca en Agrigenòmica)
Corujo, Maria (Centre de Recerca en Agrigenòmica)
Pla, Maria (Universitat de Girona)
Kleter, Gijs A. (Wageningen University and Research Centre)
Kok, Esther J. (Wageningen University and Research Centre)
Sharbati, Jutta (Freie Universität Berlin. Institute of Veterinary Biochemistry)
Hanisch, Carlos (Freie Universität Berlin. Institute of Veterinary Biochemistry)
Einspanier, Ralf (Freie Universität Berlin. Institute of Veterinary Biochemistry)
Adel-Patient, Karine (Institut national de la recherche agronomique. Unité d'Immuno-Allergie Alimentaire)
Wal, Jean‑Michel (Institut national de la recherche agronomique. Unité d'Immuno-Allergie Alimentaire)
Spök, Armin (IFZ-Inter-University Research Centre for Technology. Work and Culture)
Pöting, Annette (Federal Institute for Risk Assessment)
Kohl, Christian (Julius Kühn Institute. Institute for Biosafety in Plant Biotechnology)
Wilhelm, Ralf (Julius Kühn Institute. Institute for Biosafety in Plant Biotechnology)
Schiemann, Joachim (Julius Kühn Institute. Institute for Biosafety in Plant Biotechnology)
Steinberg, Pablo (University of Veterinary Medicine Hannover. Institute for Food Toxicology and Analytical Chemistry)

Fecha: 2014
Resumen: The GMO Risk Assessment and Communication of Evidence (GRACE; www. grace-fp7. eu) project is funded by the European Commission within the 7th Framework Programme. A key objective of GRACE is to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of two 90-day feeding trials with two different GM maize MON810 varieties, their near-isogenic non-GM varieties and four additional conventional maize varieties are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 408. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after subchronic exposure, independently of the two different genetic backgrounds of the event.
Nota: Número d'acord de subvenció EC/FP7/311957
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès
Documento: article ; recerca ; publishedVersion
Materia: Food/Feed Guidance Document of the EFSA Scientific Committee (2011) ; Genetically modified maize MON810 ; GRACE ; Rat feeding trial ; Subchronic oral toxicity study
Publicado en: Archives of Toxicology, Vol. 88, Issue 12 (December 2014) , p. 2289-2314, ISSN 1432-0738

DOI: 10.1007/s00204-014-1374-8
PMID: 25270621


26 p, 1.5 MB

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