Modification of bacterial effector proteins inside Eukaryotic host cells
Popa, Crina (Centre de Recerca en Agrigenòmica)
Tabuchi, Mitsuaki (Kagawa University. Department of Applied Biological Science)
Valls, Marc (Centre de Recerca en Agrigenòmica)

Fecha:	2016
Resumen:	Pathogenic bacteria manipulate their hosts by delivering a number of virulence proteins -called effectors- directly into the plant or animal cells. Recent findings have shown that such effectors can suffer covalent modifications inside the eukaryotic cells. Here, we summarize the recent reports where effector modifications by the eukaryotic machinery have been described. We restrict our focus on proteins secreted by the type III or type IV systems, excluding other bacterial toxins. We describe the known examples of effectors whose enzymatic activity is triggered by interaction with plant and animal cell factors, including GTPases, E2-Ubiquitin conjugates, cyclophilin and thioredoxins. We focus on the structural interactions with these factors and their influence on effector function. We also review the described examples of host-mediated post-translational effector modifications which are required for proper subcellular location and function. These host-specific covalent modifications include phosphorylation, ubiquitination, SUMOylation, and lipidations such as prenylation, fatty acylation and phospholipid binding.
Ayudas:	Ministerio de Economía y Competitividad AGL2013-46898-R
Nota:	Altres ajuts: COST Action FA1208 Sustain funded by the European Union H2020
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Type III secretion system ; Type IV secretion system ; Bacterial effector ; Bacterial virulence ; Eukaryotic host ; Animal pathogens ; Plant pathogens
Publicado en:	Frontiers in cellular and infection microbiology, Vol. 6 (July 2016) , art. 73, ISSN 2235-2988

DOI: 10.3389/fcimb.2016.00073
PMID: 27489796

13 p, 1.2 MB

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