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Modification of bacterial effector proteins inside Eukaryotic host cells
Popa, Crina (Centre de Recerca en Agrigenòmica)
Tabuchi, Mitsuaki (Kagawa University. Department of Applied Biological Science)
Valls, Marc (Centre de Recerca en Agrigenòmica)

Date: 2016
Abstract: Pathogenic bacteria manipulate their hosts by delivering a number of virulence proteins -called effectors- directly into the plant or animal cells. Recent findings have shown that such effectors can suffer covalent modifications inside the eukaryotic cells. Here, we summarize the recent reports where effector modifications by the eukaryotic machinery have been described. We restrict our focus on proteins secreted by the type III or type IV systems, excluding other bacterial toxins. We describe the known examples of effectors whose enzymatic activity is triggered by interaction with plant and animal cell factors, including GTPases, E2-Ubiquitin conjugates, cyclophilin and thioredoxins. We focus on the structural interactions with these factors and their influence on effector function. We also review the described examples of host-mediated post-translational effector modifications which are required for proper subcellular location and function. These host-specific covalent modifications include phosphorylation, ubiquitination, SUMOylation, and lipidations such as prenylation, fatty acylation and phospholipid binding.
Note: Altres ajuts: COST Action FA1208 Sustain funded by the European Union H2020
Note: Número d'acord de subvenció MINECO/AGL2013-46898-R
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Type III secretion system ; Type IV secretion system ; Bacterial effector ; Bacterial virulence ; Eukaryotic host ; Animal pathogens ; Plant pathogens
Published in: Frontiers in cellular and infection microbiology, Vol. 6 (July 2016) , art. 73, ISSN 2235-2988

DOI: 10.3389/fcimb.2016.00073
PMID: 27489796

13 p, 1.2 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Experimental sciences > CRAG (Centre for Research in Agricultural Genomics)
Articles > Research articles
Articles > Published articles

 Record created 2020-01-31, last modified 2020-11-07

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