Return to the sea, get huge, beat cancer : An analysis of Cetacean genomes including an assembly for the humpback whale (Megaptera novaeangliae)
Tollis, Marc (Northern Arizona University. School of Informatics, Computing and Cyber Systems)
Robins, Jooke (Center for Coastal Studies (USA))
Webb, Andrew E. (Temple University. Center for Computational Genetics and Genomics)
Kuderna, Lukas (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Caulin, Aleah F. (University of Pennsylvania. Genomics and Computational Biology Program)
Garcia, Jacinda D. (Arizona State University. School of Life Sciences)
Bèrubè, Martine (University of Groningen. Groningen Institute of Evolutionary Life Sciences)
Pourmand, Nader (University of California Santa Cruz. Jack Baskin School of Engineering)
Marquès i Bonet, Tomàs 1975- (Institut Català de Paleontologia Miquel Crusafont)
O'Connell, Mary J. (University of Nottingham. Computational and Molecular Evolutionary Biology Research Group)
Palsbøll, Per J. (University of Groningen. Groningen Institute of Evolutionary Life Sciences)
Maley, Carlo C. (Arizona State University. School of Life Sciences)

Fecha:	2019
Resumen:	Cetaceans are a clade of highly specialized aquatic mammals that include the largest animals that have ever lived. The largest whales can have ∼1,000× more cells than a human, with long lifespans, leaving them theoretically susceptible to cancer. However, large-bodied and long-lived animals do not suffer higher risks of cancer mortality than humans - an observation known as Peto's Paradox. To investigate the genomic bases of gigantism and other cetacean adaptations, we generated a de novo genome assembly for the humpback whale (Megaptera novaeangliae) and incorporated the genomes of ten cetacean species in a comparative analysis. We found further evidence that rorquals (family Balaenopteridae) radiated during the Miocene or earlier, and inferred that perturbations in abundance and/or the interocean connectivity of North Atlantic humpback whale populations likely occurred throughout the Pleistocene. Our comparative genomic results suggest that the evolution of cetacean gigantism was accompanied by strong selection on pathways that are directly linked to cancer. Large segmental duplications in whale genomes contained genes controlling the apoptotic pathway, and genes inferred to be under accelerated evolution and positive selection in cetaceans were enriched for biological processes such as cell cycle checkpoint, cell signaling, and proliferation. We also inferred positive selection on genes controlling the mammalian appendicular and cranial skeletal elements in the cetacean lineage, which are relevant to extensive anatomical changes during cetacean evolution. Genomic analyses shed light on the molecular mechanisms underlying cetacean traits, including gigantism, and will contribute to the development of future targets for human cancer therapies.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cetaceans ; Humpback whale ; Evolution ; Genome ; Cancer
Publicado en:	Molecular biology and evolution, Vol. 36, Issue 8 (August 2019) , p. 1746-1763, ISSN 1537-1719

DOI: 10.1093/molbev/msz099
PMID: 31070747

18 p, 641.8 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias > Institut Català de Paleontologia Miquel Crusafont (ICP)
Artículos > Artículos de investigación
Artículos > Artículos publicados