Web of Science: 3 citations, Scopus: 2 citations, Google Scholar: citations,
Effects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients : a randomized controlled trial
Montero-Marín, Jesús (RedIAPP (Red de Investigación en Actividades Preventivas y Promoción de la Salud))
Andrés-Rodríguez, Laura (Universitat Autònoma de Barcelona. Departament de Psicologia Bàsica, Evolutiva i de l'Educació)
Tops, Mattie (Vrije Universiteit)
Luciano, Juan V. (Parc Sanitari Sant Joan de Déu)
Navarro-Gil, Mayte (Universidad de Zaragoza. Departamento de Psicología i Sociología)
Feliu-Soler, Albert (Parc Sanitari Sant Joan de Déu)
López-del-Hoyo, Yolanda (Universidad de Zaragoza. Departamento de Psicología i Sociología)
Garcia-Campayo, Javier (Hospital Universitario Miguel Servet)

Date: 2019
Abstract: Fibromyalgia (FM) is a disabling syndrome characterized by chronic pain associated with fatigue. Its pathogenesis is unknown, but alterations in central sensitization, involving an imbalance of brain-derived neurotrophic factor (BDNF) and inflammatory biomarkers, appear to be implicated. The aim of this study was to evaluate the impact of attachment-based compassion therapy (ABCT) on levels of BDNF, the inflammatory markers TNF-α, IL-6, IL-10, and the C-reactive protein (CRP), analysing whether biomarkers play a mediating/moderating role in improvements in FM functional status. Thirty-four female patients with FM participated in a RCT and were assigned to ABCT or relaxation therapy. Blood extractions were conducted at baseline and post-intervention, with self-report assessments of functional status (FIQ) at baseline, post-intervention and 3-month follow-up. A pro-inflammatory composite was obtained by summing up IL-6, TNF-α and CRP normalized values. Non-parametric tests, analysis of variance and regression models were used to evaluate treatment and mediation/moderation. Compared to relaxation therapy, ABCT showed significant improvements in FIQ and decreases in BDNF, CRP, and pro-inflammatory composite. Changes in BDNF had a mediating role in FIQ. ABCT seems to reduce BDNF and appears to have anti-inflammatory effects in FM patients. Reductions in BDNF could be a mechanism of FM functional status improvement. Clinical Trial Registration:http://ClinicalTrials. gov, identifier NCT02454244. Date: May 27th, 2015.
Note: Número d'acord de subvenció RD06/0018/0017
Note: Número d'acord de subvenció ISCIII/RD16/0007/0005
Note: Número d'acord de subvenció ISCIII/RD16/0007/0012
Note: Número d'acord de subvenció ISCIII/CP14/00087
Note: Número d'acord de subvenció ISCIII/CD16/00147
Note: Número d'acord de subvenció AGAUR/2018/FI_B 00783
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Published in: Scientific reports (Nature Publishing Group), Vol. 9, núm. 1 (january 2019) , p. 15639, ISSN 2045-2322

DOI: 10.1038/s41598-019-52260-z
PMID: 31666651

14 p, 1.8 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2020-06-03, last modified 2021-01-18

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