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| Página principal > Artículos > Artículos publicados > Association of lifestyle factors and inflammation with sarcopenic obesity : |
(Universidad de Navarra) (Institut d'Investigació Sanitària i Biomèdica d'Alacant - Fundació FISABIO) (Instituto de Investigación Sanitaria de Navarra) (Instituto de Salud Carlos III) (Instituto de Salud Carlos III) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Universidad de Navarra) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Instituto de Salud Carlos III) (Hospital Universitari de Bellvitge) (Hospital Universitari de Bellvitge) (Instituto de Biomedicina, León) (Universidad de León) (IMDEA Food Institute, Madrid) (Universitat Autònoma de Barcelona. Departament de Medicina) (Institut d'Investigació Sanitària Pere Virgili) (Institut d'Investigació Sanitària i Biomèdica d'Alacant - Fundació FISABIO) (IMDEA Food Institute, Madrid)
| Fecha: | 2019 |
| Resumen: | Background: Sarcopenia is a progressive age-related skeletal muscle disorder associated with increased likelihood of adverse outcomes. Muscle wasting is often accompanied by an increase in body fat, leading to 'sarcopenic obesity'. The aim of the present study was to analyse the association of lifestyle variables such as diet, dietary components, physical activity (PA), body composition, and inflammatory markers, with the risk of sarcopenic obesity. Methods: A cross-sectional analysis based on baseline data from the PREDIMED-Plus study was performed. A total of 1535 participants (48% women) with overweight/obesity (body mass index: 32. 5 ± 3. 3 kg/m; age: 65. 2 ± 4. 9 years old) and metabolic syndrome were categorized according to sex-specific tertiles (T) of the sarcopenic index (SI) as assessed by dual-energy X-ray absorptiometry scanning. Anthropometrical measurements, biochemical markers, dietary intake, and PA information were collected. Linear regression analyses were carried out to evaluate the association between variables. Results: Subjects in the first SI tertile were older, less physically active, showed higher frequency of abdominal obesity and diabetes, and consumed higher saturated fat and less vitamin C than subjects from the other two tertiles (all P < 0. 05). Multiple adjusted linear regression models evidenced significant positive associations across tertiles of SI with adherence to the Mediterranean dietary score (P-trend < 0. 05), PA (P-trend < 0. 0001), and the 30 s chair stand test (P-trend < 0. 0001), whereas significant negative associations were found with an inadequate vitamin C consumption (P-trend < 0. 05), visceral fat and leucocyte count (all P-trend < 0. 0001), and some white cell subtypes (neutrophils and monocytes), neutrophil-to-lymphocyte ratio, and platelet count (all P-trend < 0. 05). When models were additionally adjusted by potential mediators (inflammatory markers, diabetes, and waist circumference), no relevant changes were observed, only dietary variables lost significance. Conclusions: Diet and PA are important regulatory mediators of systemic inflammation, which is directly involved in the sarcopenic process. A healthy dietary pattern combined with exercise is a promising strategy to limit age-related sarcopenia. |
| Ayudas: | Instituto de Salud Carlos III PI13-00462 Instituto de Salud Carlos III PI13-01090 Instituto de Salud Carlos III PI13-02184 Instituto de Salud Carlos III PI14-00853 Instituto de Salud Carlos III PI14-00728 Instituto de Salud Carlos III PI14-01919 Instituto de Salud Carlos III PI16-00501 Instituto de Salud Carlos III PI16-00381 Instituto de Salud Carlos III PI16-01522 Instituto de Salud Carlos III PI17-00525 Instituto de Salud Carlos III PI17-00532 Instituto de Salud Carlos III PI17-00215 Instituto de Salud Carlos III PI17-00926 Ministerio de Economía y Competitividad FJCI-2015-24058 European Commission 340918 |
| Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.  |
| Lengua: | Anglès |
| Documento: | Article ; recerca ; Versió publicada |
| Materia: | Sarcopenic index ; Visceral fat ; Leucocyte count ; Mediterranean diet score ; Systemic inflammation ; Physical activity |
| Publicado en: | Journal of Cachexia, Sarcopenia and Muscle, Vol. 10 Núm. 5 (january 2019) , p. 974-984, ISSN 2190-6009 |
