Soy isoflavone extract does not increase the intoxicating effects of acute alcohol ingestion in human volunteers
Martínez-Riera, R. (Institut Hospital del Mar d'Investigacions Mèdiques)
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fonseca, Francina 1972- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
De La Torre, Rafael (Institut Hospital del Mar d'Investigacions Mèdiques)
Pizarro Lozano, Nieves (Institut Hospital del Mar d'Investigacions Mèdiques)
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Farré Albaladejo, Magí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Fecha:	2019
Resumen:	Soy beans contain isoflavones, including daidzein and genistein, with biological activities related to therapeutic effects in reducing osteoporosis, decreasing adverse menopausal manifestations, providing protection from cardiovascular diseases, and reducing hormone-dependent cancers and age-related cognitive-decline. Daidzein has been described as inhibiting the aldehyde-dehydrogenase-2 enzyme (ALDH2), and reducing alcohol use in clinical pilot studies. Our aim was to evaluate the possible interactions between a soy extract product and alcohol in a crossover, single blind, randomized study. Ten healthy male volunteers participated in two experimental sessions: one with a single dose of alcohol (0. 5 g/kg, Vodka Absolut, Sweden), and the other with four capsules of a soy extract product (Super-Absorbable Soy Isoflavones, Life-Extension, United States) and, 2 h later, the same dose of alcohol. Results showed no differences in vital signs except a slightly higher significative reduction in diastolic blood pressure at 2, 3, 4, and 8 h after administration with alcohol alone in comparison with soy extract+alcohol. Ethanol-induced subjective and adverse effects were similar for both conditions with the exception of headache (higher at 8 h after alcohol alone). Our results demonstrate that a single dose of a soy isoflavone extract did not influence alcohol pharmacokinetics and pharmacological effects and did not induce any disulfiram-reaction symptoms. Soy extract and alcohol did not interact and can be administered safely.
Ayudas:	Instituto de Salud Carlos III RD16-0017-0003 Instituto de Salud Carlos III JR16-00020 Instituto de Salud Carlos III RD16-0017-0010
Nota:	Altres ajuts: This work was supported by grants from Ministerio de Sanidad, Política Social e Igualdad (Plan Nacional Sobre Drogas, PNSD 2015I054 and 2016I024).
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Soy extracts ; Isoflavones, daidzein ; Genistein ; Aldehyde-dehydrogenase-2 enzyme ; Alcohol ; Clinical trial
Publicado en:	Frontiers in Pharmacology, Vol. 10 Núm. FEB (2019) , p. 131, ISSN 1663-9812

DOI: 10.3389/fphar.2019.00131
PMID: 30873023

8 p, 978.1 KB

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