Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms
Ghosh, Eshan (Indian Institute of Technology, Kanpur)
Dwivedi, Hemlata (Indian Institute of Technology, Kanpur)
Baidya, Mithu (Indian Institute of Technology, Kanpur)
Srivastava, Ashish (Indian Institute of Technology, Kanpur)
Kumari, Punita (Indian Institute of Technology, Kanpur)
Stepniewski, Tomek (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Kim, Hee Ryung (Sungkyunkwan University, South Korea)
Lee, Mi-Hye (Medical University of South Carolina)
van Gastel, Jana (University of Antwerp)
Chaturvedi, Madhu (Indian Institute of Technology, Kanpur)
Roy, Debarati (Indian Institute of Technology, Kanpur)
Pandey, Shubhi (Indian Institute of Technology, Kanpur)
Maharana, Jagannath (Indian Institute of Technology, Kanpur)
Guixà González, Ramon (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional)
Luttrell, Louis M. (Medical University of South Carolina)
Chung, Ka Young (Sungkyunkwan University, South Korea)
Dutta, Somnath (Indian Institute of Sciences, Bangalore)
Selent, Jana (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Shukla, Arun K. (Indian Institute of Technology, Kanpur)

Date:	2019
Abstract:	Ghosh et al. discover structural differences between β-arrestin isoforms (β-arrestin 1 and 2), which are universal regulators of signaling and trafficking of G-protein-coupled receptors (GPCRs). These findings have direct implications for understanding the regulatory and signaling paradigms of GPCRs and designing novel therapeutics targeting this important class of receptors.
Grants:	Instituto de Salud Carlos III PI15/0046 Instituto de Salud Carlos III PI18/00094
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	GPCRs ; β-arrestins ; Cellular signaling ; Antibody fragments ; Biosensors ; Biased agonism ; Desensitization ; Negative staining ; Electron microscopy
Published in:	Cell reports, Vol. 28 Núm. 13 (24 2019) , p. 3287-3299.e6, ISSN 2211-1247

DOI: 10.1016/j.celrep.2019.08.053
PMID: 31553900

20 p, 4.2 MB

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