Iodine Status, Thyroid Function, and Birthweight : A Complex Relationship in High-Risk Pregnancies
Velasco, Inés (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sánchez-Gila, Mar (Hospital Universitario Virgen de las Nieves (Granada))
Manzanares, Sebastián (Hospital Universitario Virgen de las Nieves (Granada))
Taylor, Peter (Thyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, UHW, C2 Link Corridor, Heath Park, Cardiff CF14 4XN, UK)
García-Fuentes, Eduardo (Instituto de Investigación Biomédica de Málaga)
Universitat Autònoma de Barcelona

Fecha:	2020
Resumen:	(1) Background: The consequences of iodine deficiency and/or thyroid dysfunction during pregnancy have been extensively studied, emphasizing on infant neurodevelopment. However, the available information about the relationship between iodine, thyroid hormones, and fetal growth in high-risk pregnancies is limited. We aim to investigate if iodine metabolism and/or thyroid parameters can be affected by adverse antenatal/perinatal conditions. (2) Methods: A cross-sectional study examined differences in iodine status, thyroid function, and birthweight between high-risk (HR group; n = 108)) and low-risk pregnancies (LR group; n = 233) at the time of birth. Urinary iodine concentration (UIC), iodine levels in amniotic fluid, and thyroid parameters [thyroid-stimulating hormone (TSH), free thyroxine (FT4)] were measured in mother-baby pairs. (3) Results: There were significant differences between HR and LR groups, free thyroxine (FT4) concentration in cord blood was significantly higher in the LR group compared with HR pregnancies (17. 06 pmol/L vs. 15. 30 pmol/L, respectively; p < 0. 001), meanwhile iodine concentration in amniotic fluid was significantly lower (13. 11 µg/L vs. 19. 65 µg/L, respectively; p < 0. 001). (4) Conclusions: Our findings support the hypothesis that an adverse intrauterine environment can compromise the availability of FT4 in cord blood as well as the iodine metabolism in the fetus. These differences are more noticeable in preterm and/or small fetuses.
Ayudas:	Instituto de Salud Carlos III PI15-02200 Instituto de Salud Carlos III PI18-0185
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Iodine ; Thyroid function ; Birthweight ; Amniotic fluid ; High-risk pregnancy
Publicado en:	Journal of clinical medicine, Vol. 9 (january 2020) , ISSN 2077-0383

DOI: 10.3390/jcm9010177
PMID: 31936405

13 p, 685.9 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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