Sudan red dye : a new agent causing type-2 occupational asthma
Clofent, David (Hospital Universitari Vall d'Hebron)
de Homdedeu, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Muñoz-Esquerre, Mariana (Institut d'Investigació Biomèdica de Bellvitge)
Cruz Carmona, María Jesús (Hospital Universitari Vall d'Hebron)
Muñoz Gall, Xavier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)

Date:	2020
Abstract:	Sudan red or 1-[(2-methoxyphenyl)azo]-2-naphthol is a low molecular weight azoic agent widely used in industry, particularly in the production of hair dyes. The use of this product in the food industry is prohibited due to its potential carcinogenic effect, but no respiratory involvement has been reported to date. We present the case of a 46-year-old female patient who had been working in a cosmetics packaging company for 20 years. The patient developed occupational asthma to a red azo dye known as Sudan red. The diagnosis was confirmed by specific bronchial provocation test. Induced sputum samples were obtained previously and in the 24 h following the procedure, with a rise in the percentage of eosinophils from 10 to 65%. This report describes the case of a patient who developed OA caused by exposure to an azoic dye called Sudan red. The clinical and analytical features suggest a type 2-related asthma; however, we are not yet able to confirm the specific pathophysiological mechanism. The extensive use of azo dyes in industry means that it is particularly important to describe their implications for health, which are probably underestimated at present.
Grants:	Instituto de Salud Carlos III CPII17-00025
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Allergy ; Specific inhalation challenge ; Azoic agent
Published in:	Allergy, asthma, and clinical immunology, Vol. 16 (january 2020) , ISSN 1710-1492

DOI: 10.1186/s13223-020-0404-8
PMID: 32021623

3 p, 634.4 KB

The record appears in these collections:
Articles > Research articles
Articles > Published articles