The oncogenic role of hepatitis delta virus in hepatocellular carcinoma
Puigvehí, Marc (Institut Hospital del Mar d'Investigacions Mèdiques)
Moctezuma-Velázquez, Carlos (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Villanueva, Augusto (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Llovet, Josep M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Hepatitis delta virus (HDV) is a small defective virus that needs hepatitis B virus (HBV) to replicate and propagate. HDV infection affects 20-40 million people worldwide and pegylated interferon (PegIFN) is the only recommended therapy. There is limited data on the contribution of HDV infection to HBV-related liver disease or liver cancer. Evidence from retrospective and cohort studies suggests that HBV/HDV coinfection accelerates progression to cirrhosis and is associated with an increased risk of hepatocellular carcinoma (HCC) development compared to HBV monoinfection. Although the life cycle of HDV is relatively well known, there is only ancillary information on the molecular mechanisms that can drive specific HDV-related oncogenesis. No thorough reports on the specific landscape of mutations or molecular classes of HDV-related HCC have been published. This information could be critical to better understand the uniqueness, if any, of HDV-related HCC and help identify novel targetable mutations. Herein, we review the evidence supporting an oncogenic role of HDV, the main reported mechanisms of HDV involvement and their impact on HCC development.
Grants:	European Commission 667273 Instituto de Salud Carlos III SAF2016-76390
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article de revisió ; Article ; Versió publicada
Subject:	Hepatitis B virus ; Liver cancer ; HCC, co-infection ; Molecular pathogenesis ; Defective ; Superinfection
Published in:	JHEP Reports, Vol. 1 (may 2019) , p. 120-130, ISSN 2589-5559

DOI: 10.1016/j.jhepr.2019.05.001
PMID: 32039360

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