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000226317 024 7_ $2 doi $a 10.1534/g3.118.200789
000226317 024 8_ $9 scholar $9 driver $9 artpubuab $a oai:ddd.uab.cat:226317
000226317 035 __ $9 pmid $a 30658967
000226317 035 __ $9 pmcid $a PMC6404621
000226317 035 __ $9 pmc-uid $a 6404621
000226317 035 __ $9 articleid $a 21601836v9p855
000226317 035 __ $a oai:egreta.uab.cat:publications/981d1921-dcb6-4162-a20c-35ebe74f519b
000226317 035 __ $9 scopus_id $a 85062611410
000226317 035 __ $a oai:pubmedcentral.nih.gov:6404621
000226317 041 __ $a eng
000226317 100 10 $0 0000-0002-7819-4541 $a Fablet, Marie $u Université de Lyon. Laboratoire de Biométrie et Biologie Evolutive
000226317 245 10 $a Dynamic Interactions Between the Genome and an Endogenous Retrovirus : $b Tirant in Drosophila simulans Wild-Type Strains
000226317 251 __ $1 http://purl.org/coar/version/c_970fb48d4fbd8a85 $2 openaire4 $9 VoR $a Versió publicada
000226317 260 __ $c 2019
000226317 520 3_ $a All genomes contain repeated sequences that are known as transposable elements (TEs). Among these are endogenous retroviruses (ERVs), which are sequences similar to retroviruses and are transmitted across generations from parent to progeny. These sequences are controlled in genomes through epigenetic mechanisms. At the center of the epigenetic control of TEs are small interfering RNAs of the piRNA class, which trigger heterochromatinization of TE sequences. The tirant ERV of Drosophila simulans displays intra-specific variability in copy numbers, insertion sites, and transcription levels, providing us with a well-suited model to study the dynamic relationship between a TE family and the host genome through epigenetic mechanisms. We show that tirant transcript amounts and piRNA amounts are positively correlated in ovaries in normal conditions, unlike what was previously described following divergent crosses. In addition, we describe tirant insertion polymorphism in the genomes of three D. simulans wild-type strains, which reveals a limited number of insertions that may be associated with gene transcript level changes through heterochromatin spreading and have phenotypic impacts. Taken together, our results participate in the understanding of the equilibrium between the host genome and its TEs.
000226317 540 __ $9 open access $a Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. $u https://creativecommons.org/licenses/by/4.0/
000226317 546 __ $a Anglès
000226317 599 __ $a recerca
000226317 653 1_ $a Transposable element
000226317 653 1_ $a Retrotransposon
000226317 653 1_ $a Drosophila
000226317 653 1_ $a Epigenetic control
000226317 653 1_ $a Pirna
000226317 653 1_ $a Chromatin
000226317 655 _7 $1 http://purl.org/coar/resource_type/c_6501 $2 openaire4 $a Article $c literature
000226317 700 10 $a Jacquet, Angelo $u Université de Lyon. Laboratoire de Biométrie et Biologie Evolutive
000226317 700 10 $a Rebollo, Rita $u Université de Lyon. INSA-Lyon, INRA
000226317 700 10 $a Haudry, Annabelle $u Université de Lyon. Laboratoire de Biométrie et Biologie Evolutive
000226317 700 10 $a Rey, Carine $u Université de Lyon. Laboratoire de Biologie et Modélisation de la Cellule
000226317 700 10 $a Salces-Ortiz, Judit $u Université de Lyon. Laboratoire de Biométrie et Biologie Evolutive
000226317 700 10 $a Bajad, Prajakta $u Medical University of Vienna. Center for Anatomy and Cell Biology, Division of Cell- and Developmental Biology
000226317 700 10 $a Burlet, Nelly $u Université de Lyon. Laboratoire de Biométrie et Biologie Evolutive
000226317 700 10 $a Jantsch, Michael F. $u Medical University of Vienna. Center for Anatomy and Cell Biology, Division of Cell- and Developmental Biology
000226317 700 10 $0 0000-0001-9951-1879 $a García Guerreiro, María Pilar $u Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia
000226317 700 10 $0 0000-0003-3414-3993 $a Vieira, Cristina $u Université de Lyon. Laboratoire de Biométrie et Biologie Evolutive
000226317 773 __ $g Vol. 9, Num. 3 (March 2019), p. 855-865 $t G3 $x 2160-1836
000226317 856 40 $p 11 $s 1732447 $u https://ddd.uab.cat/pub/artpub/2019/pmc_30658967/pmc_30658967.pdf
000226317 973 __ $f 855 $l 865 $m 1 $v 9 $x g3:genes,genomes,genetics_a2019m1v9n $y 2019
000226317 980 __ $a ARTPUB $b UAB