Abdominal distension after eating lettuce : The role of intestinal gas evaluated in vitro and by abdominal CT imaging
Barba Orozco, Elizabeth (Hospital Universitari Vall d'Hebron)
Sánchez, Borja (Instituto de Investigación Sanitaria del Principado de Asturias)
Burri, Emanuel (Kantonsspital Baselland)
Accarino, Ana María (Universitat Autònoma de Barcelona. Departament de Medicina)
Monclús, Eva (Universitat Politècnica de Catalunya)
Navazo, Isabel (Universitat Politècnica de Catalunya)
Guarner, Francisco (Universitat Autònoma de Barcelona. Departament de Medicina)
Margolles, Abelardo (Instituto de Investigación Sanitaria del Principado de Asturias)
Azpiroz Vidaur, Fernando (Universitat Autònoma de Barcelona. Departament de Medicina)

Fecha:	2019
Resumen:	Some patients complain that eating lettuce, gives them gas and abdominal distention. Our aim was to determine to what extent the patients' assertion is sustained by evidence. An in vitro study measured the amount of gas produced during the process of fermentation by a preparation of human colonic microbiota (n = 3) of predigested lettuce, as compared to beans, a high gas-releasing substrate, to meat, a low gas-releasing substrate, and to a nutrient-free negative control. A clinical study in patients complaining of abdominal distention after eating lettuce (n = 12) measured the amount of intestinal gas and the morphometric configuration of the abdominal cavity in abdominal CT scans during an episode of lettuce-induced distension as compared to basal conditions. Gas production by microbiota fermentation of lettuce in vitro was similar to that of meat (P = . 44), lower than that of beans (by 78 ± 15%; P < . 001) and higher than with the nutrient-free control (by 25 ± 19%; P = . 05). Patients complaining of abdominal distension after eating lettuce exhibited an increase in girth (35 ± 3 mm larger than basal; P < . 001) without significant increase in colonic gas content (39 ± 4 mL increase; P = . 071); abdominal distension was related to a descent of the diaphragm (by 7 ± 3 mm; P = . 027) with redistribution of normal abdominal contents. Lettuce is a low gas-releasing substrate for microbiota fermentation and lettuce-induced abdominal distension is produced by an uncoordinated activity of the abdominal walls. Correction of the somatic response might be more effective than the current dietary restriction strategy. In some patients lettuce produces abdominal distension, which is not related to gas, but rather to an uncontrolled reaction of the abdominal muscles and the diaphragm. Hence, learning to control the abdominal muscles may prevent distension with no need of dietary restrictions.
Ayudas:	Ministerio de Economía y Competitividad SAF-2016-76648-R
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Abdominal distension ; Diaphragmatic activity ; Functional gut disorders ; Intestinal gas ; Lettuce
Publicado en:	Neurogastroenterology and Motility, Vol. 31 (august 2019) , ISSN 1365-2982

DOI: 10.1111/nmo.13703
PMID: 31402544

7 p, 797.7 KB

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