Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength : state of the art-outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)
Díez Pérez, Adolfo (Universitat Autònoma de Barcelona. Departament de Medicina)
Brandi, Maria Luisa (University of Florence. Department of Biological, Experimental and Clinical Science)
Al-Daghri, Nasser (King Saud University. Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science)
Branco, Jaime (Universidade Nova de Lisboa. NOVA Medical School)
Bruyère, Olivier (Université de Liège)
Cavalli, Loredana (University of Florence. Department of Biological, Experimental and Clinical Science)
Cooper, Cyrus (University Hospital Southampton NHS Foundation Trust (Regne Unit))
Cortet, Bernard (University Hospital of Lille (França))
Dawson-Hughes, Bess (Tufts University. Bone Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging)
Dimai, Hans Peter (Medical University of Graz. Department of Internal Medicine, Division of Endocrinology and Diabetology)
Gonnelli, Stefano (University of Siena. Department of Medicine, Surgery and Neurosciences)
Hadji, Peyman (Frankfurter Hormon und Osteoporose Zentrum, Frankfurt, Germany)
Halbout, Philippe (International Osteoporosis Foundation, Nyon, Switzerland)
Kaufman, Jean-Marc (Universitair Ziekenhuis Gent)
Kurth, Andreas (Mayor Teaching Hospital, Charite Medical School)
Locquet, Medea (University of Liège. Department of Public Health, Epidemiology and Health Economics)
Maggi, Stefania (Institute of Neuroscience. National Research Council, Aging Program)
Matijevic, Radmila (Clinical Center of Vojvodina, Clinic for Orthopedic Surgery)
Reginster, Jean-Yves (Université de Liège)
Rizzoli, René (Geneva University Hospitals (Suïssa))
Thierry, Thomas (University of Lyon. INSERM 1059)

Data:	2019
Resum:	The purpose of this paper was to review the available approaches for bone strength assessment, osteoporosis diagnosis and fracture risk prediction, and to provide insights into radiofrequency echographic multi spectrometry (REMS), a non-ionizing axial skeleton technique. A working group convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis met to review the current image-based methods for bone strength assessment and fracture risk estimation, and to discuss the clinical perspectives of REMS. Areal bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is the consolidated indicator for osteoporosis diagnosis and fracture risk assessment. A more reliable fracture risk estimation would actually require an improved assessment of bone strength, integrating also bone quality information. Several different approaches have been proposed, including additional DXA-based parameters, quantitative computed tomography, and quantitative ultrasound. Although each of them showed a somewhat improved clinical performance, none satisfied all the requirements for a widespread routine employment, which was typically hindered by unclear clinical usefulness, radiation doses, limited accessibility, or inapplicability to spine and hip, therefore leaving several clinical needs still unmet. REMS is a clinically available technology for osteoporosis diagnosis and fracture risk assessment through the estimation of BMD on the axial skeleton reference sites. Its automatic processing of unfiltered ultrasound signals provides accurate BMD values in view of fracture risk assessment. New approaches for improved bone strength and fracture risk estimations are needed for a better management of osteoporotic patients. In this context, REMS represents a valuable approach for osteoporosis diagnosis and fracture risk prediction.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Bone strength assessment ; Osteoporosis diagnosis ; Fracture risk ; REMS ; Ultrasound ; Lumbar spine ; Femoral neck
Publicat a:	Aging Clinical and Experimental Research, Vol. 31 (august 2019) , p. 1375-1389, ISSN 1720-8319

DOI: 10.1007/s40520-019-01294-4
PMID: 31422565

15 p, 1.0 MB

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