The role of schizotypal traits and the OXTR gene in theory of mind in schizophrenia : A family-based study
Giralt López, Maria (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Miret, S. (Hospital Universitari Santa Maria (Lleida))
Soler, J. (Universitat de Barcelona)
Campanera i Reig, Sílvia (Hospital Universitari Santa Maria (Lleida))
Parellada, M. (Hospital General Universitario Gregorio Marañón)
Fañanás Saura, Lourdes (Universitat de Barcelona)
Fatjó-Vilas, Mar (Universitat de Barcelona)

Fecha:	2020
Resumen:	There is consistent evidence that theory of mind (ToM) is impaired in schizophrenia (SZ); however, it remains unclear whether such deficits are trait- or state-dependent. We evaluated ToM in patients with schizophrenia spectrum disorders (SSDs), their healthy first-degree relatives, and controls to test its suitability as an endophenotypic marker. We also studied the modifying effect of markers of clinical and genetic liability to SZ (schizotypy and genetic variability in the oxytocin receptor gene: OXTR) on ToM in healthy individuals. The sample included 38 stable SSD patients, 80 unaffected first-degree relatives, and 81 controls. ToM was assessed using the Hinting Task (HT) and schizotypy via the Schizotypal Personality Questionnaire-Brief (SPQ-B), which generates interpersonal (SPQ-IP), cognitive-perceptual (SPQ-CP), and disorganization (SPQ-D) scores. The polymorphism rs53576 of OXTR was genotyped. Patients presented poorer HT performance than relatives and controls (p = 0. 003 and p < 0. 001). High SPQ-IP and SPQ-CP scores correlated with poorer ToM performance in relatives (p = 0. 010 and p = 0. 030), but not in controls. OXTR was not associated with HT scores, but it showed a modifying effect within controls; high SPQ-CP was related to HT poorer performance conditional to GG genotype (p = 0. 007). ToM deficits were present in patients but not in unaffected relatives or controls. However, our data indicate the usefulness of clinical and genetic liability markers to characterize differences in ToM abilities within healthy individuals. Then, the observed link between ToM and SZ liability suggests the putative role of ToM as an endophenotypic marker. Nevertheless, new analyses in larger samples are needed.
Ayudas:	Instituto de Salud Carlos III PI15-01420 Instituto de Salud Carlos III CD16-00264 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1577 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1271
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Family-based study ; OXTR gene ; Schizophrenia ; Schizotypy ; Theory of mind
Publicado en:	European psychiatry, Vol. 63 (february 2020) , ISSN 1778-3585

DOI: 10.1192/j.eurpsy.2019.17
PMID: 32093796

8 p, 208.7 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Artículos > Artículos de investigación
Artículos > Artículos publicados