Home > Articles > Published articles > Acute Effects of 2C-E in Humans : |
Date: | 2020 |
Abstract: | 2,5-Dimethoxy-4-ethylphenethylamine (2C-E) is psychedelic phenylethylamine, with a chemical structure similar to mescaline, used as new psychoactive substance (NPS). It inhibits norepinephrine and serotonin uptake and, more relevant, acts as a partial agonist of the serotonin 2A (5-HT), 2B (5-HT), and (5-HT) receptors. Consumers have reported that 2C-E induces mild-moderate psychedelic effects, but its pharmacology in humans, including pharmacological effects and pharmacokinetics, have not yet studied. To assess the acute effects of 2C-E on physiological and subjective effects and evaluate its pharmacokinetics, an observational study was carried-out. Ten recreational users of psychedelics self-administered a single oral dose of 2C-E (6. 5, 8, 10, 15, or 25 mg). Blood pressure and heart rate were evaluated at baseline, 2, 4, and 6 h post-administration. Three rating scales were administered to evaluate subjective effects: a set of Visual Analog Scales (VAS), the 49-item short form version of the Addiction Research Centre Inventory (ARCI), and the Evaluation of the Subjective Effects of Substances with Abuse Potential (VESSPA-SSE) at baseline, 2, 4, and 6 h after self-administration. To assess 2C-E concentrations oral fluid (saliva) was collected during 6 h. 2C-E induced primarily alterations in perceptions, hallucinations, and euphoric-mood. Saliva maximal concentrations were achieved 2 h after self-administration. Administration of oral 2C-E at recreational doses produces a group of psychedelic-like effects such to 2C-B and other serotonin-acting drugs. |
Grants: | Instituto de Salud Carlos III FIS-FEDER Instituto de Salud Carlos III FIS-PI17/01962 Instituto de Salud Carlos III RD16/0017/003 Instituto de Salud Carlos III RD16/0017/0010 Instituto de Salud Carlos III JR16/00020 Instituto de Salud Carlos III CM18/00168 European Commission HOME/2014/JDRU/AG/DRUG/7082 |
Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Language: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Subject: | 2C-E (2,5-Dimethoxy-4-ethylphenethylamine) ; Novel psychoactive substances (NPS) ; Psychedelic ; Phenylethylamines ; Psychostimulants |
Published in: | Frontiers in Pharmacology, Vol. 11 (march 2020) , ISSN 1663-9812 |
13 p, 839.9 KB |