Acute Effects of 2C-E in Humans : An Observational Study
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Olesti, Eulàlia (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Torrens, Marta (Drug Addiction Program, Institut de Neuropsiquiatria i Adiccions (INAD))
Grifell, Marc (Energy Control, Associació Benestar i Desenvolupament)
Ventura, Mireia (Energy Control, Associació Benestar i Desenvolupament)
Pozo, Oscar J. (Institut Hospital del Mar d'Investigacions Mèdiques)
de Sousa Fernandes Perna, Elizabeth B.. (Maastricht University. Department of Neuropsychology and Psychopharmacology)
Ramaekers, Johannes G. (Maastricht University. Department of Neuropsychology and Psychopharmacology)
De La Torre, Rafael (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)

Date:	2020
Abstract:	2,5-Dimethoxy-4-ethylphenethylamine (2C-E) is psychedelic phenylethylamine, with a chemical structure similar to mescaline, used as new psychoactive substance (NPS). It inhibits norepinephrine and serotonin uptake and, more relevant, acts as a partial agonist of the serotonin 2A (5-HT), 2B (5-HT), and (5-HT) receptors. Consumers have reported that 2C-E induces mild-moderate psychedelic effects, but its pharmacology in humans, including pharmacological effects and pharmacokinetics, have not yet studied. To assess the acute effects of 2C-E on physiological and subjective effects and evaluate its pharmacokinetics, an observational study was carried-out. Ten recreational users of psychedelics self-administered a single oral dose of 2C-E (6. 5, 8, 10, 15, or 25 mg). Blood pressure and heart rate were evaluated at baseline, 2, 4, and 6 h post-administration. Three rating scales were administered to evaluate subjective effects: a set of Visual Analog Scales (VAS), the 49-item short form version of the Addiction Research Centre Inventory (ARCI), and the Evaluation of the Subjective Effects of Substances with Abuse Potential (VESSPA-SSE) at baseline, 2, 4, and 6 h after self-administration. To assess 2C-E concentrations oral fluid (saliva) was collected during 6 h. 2C-E induced primarily alterations in perceptions, hallucinations, and euphoric-mood. Saliva maximal concentrations were achieved 2 h after self-administration. Administration of oral 2C-E at recreational doses produces a group of psychedelic-like effects such to 2C-B and other serotonin-acting drugs.
Grants:	Instituto de Salud Carlos III FIS-FEDER Instituto de Salud Carlos III FIS-PI17/01962 Instituto de Salud Carlos III RD16/0017/003 Instituto de Salud Carlos III RD16/0017/0010 Instituto de Salud Carlos III JR16/00020 Instituto de Salud Carlos III CM18/00168 European Commission HOME/2014/JDRU/AG/DRUG/7082
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	2C-E (2,5-Dimethoxy-4-ethylphenethylamine) ; Novel psychoactive substances (NPS) ; Psychedelic ; Phenylethylamines ; Psychostimulants
Published in:	Frontiers in Pharmacology, Vol. 11 (march 2020) , ISSN 1663-9812

DOI: 10.3389/fphar.2020.00233
PMID: 32256350

13 p, 839.9 KB

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