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Multifunctional Proteins : Involvement in Human Diseases and Targets of Current Drugs
Franco Serrano, Luis (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Huerta Casado, Mario (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Hernández, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Cedano Rodríguez, Juan Antonio (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología)
Pérez-Pons, Josep A (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Mozo-Villarias, Angel (Universitat de Lleida. Departament de Medicina Experimental)
Amela Abellan, Isaac (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)

Date: 2018
Abstract: Multifunctionality or multitasking is the capability of some proteins to execute two or more biochemical functions. The objective of this work is to explore the relationship between multifunctional proteins, human diseases and drug targeting. The analysis of the proportion of multitasking proteins from the MultitaskProtDB-II database shows that 78% of the proteins analyzed are involved in human diseases. This percentage is much higher than the 17. 9% found in human proteins in general. A similar analysis using drug target databases shows that 48% of these analyzed human multitasking proteins are targets of current drugs, while only 9. 8% of the human proteins present in UniProt are specified as drug targets. In almost 50% of these proteins, both the canonical and moonlighting functions are related to the molecular basis of the disease. A procedure to identify multifunctional proteins from disease databases and a method to structurally map the canonical and moonlighting functions of the protein have also been proposed here. Both of the previous percentages suggest that multitasking is not a rare phenomenon in proteins causing human diseases, and that their detailed study might explain some collateral drug effects.
Grants: Ministerio de Economía y Competitividad BFU2013-50176-EXP
Ministerio de Economía y Competitividad BIO2013-48704-R
Agencia Estatal de Investigación BIO2017-84166R
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: Article ; recerca ; Versió publicada
Subject: Multitasking proteins ; Human diseases ; Protein function ; Drug targets
Published in: The Protein Journal, Vol. 37, Issue 5 (October 2018) , p. 444-453, ISSN 1875-8355

DOI: 10.1007/s10930-018-9790-x
PMID: 30123928


10 p, 2.5 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2020-07-13, last modified 2022-12-05



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