Covalent functionalization of multi-walled carbon nanotubes with a gadolinium chelate for efficient T1-weighted magnetic resonance imaging
Marangon, Iris (Université de Paris VII. Laboratoire Matières et Systèmes Complexes)
Ménard-Moyon, Cécilia (Centre National de la Recherche Scientifique (França))
Kolosnjaj-Tabi, Jelena (Université de Paris VII. Laboratoire Matières et Systèmes Complexes)
Béoutis, Marie Lys (Université de Paris VII. Laboratoire Matières et Systèmes Complexes)
Lartigue, Lénaic (Université de Paris VII. Laboratoire Matières et Systèmes Complexes)
Alloyeau, Damien (Université de Paris VII. Laboratoire Matériaux et Phénomènes Quantiques)
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia)
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia)
Autret, Gwennhael (Université de Paris V)
Ninjbadgar, Tsedev (Shine Mongol Institute of Technology. Faculty of Engineering)
Brougham, Dermot F. (Dublin City University. School of Chemical Sciences)
Bianco, Alberto (Centre national de la recherche scientifique. Laboratoire d'Immunopathologie et Chimie Thérapeutique)
Gazeau, Florence (Université de Paris VII. Laboratoire Matières et Systèmes Complexes)

Data:	2014
Resum:	Given the promise of carbon nanotubes (CNTs) for photothermal therapy, drug delivery, tissue engineering, and gene therapy, there is a need for non-invasive imaging methods to monitor CNT distribution and fate in the body. In this study, non-ionizing whole-body high field magnetic resonance imaging (MRI) is used to follow the distribution of water-dispersible non-toxic functionalized CNTs administrated intravenously to mice. Oxidized CNTs are endowed with positive MRI contrast properties by covalent functionalization with the chelating ligand diethylenetriaminepentaacetic dianhydride (DTPA), followed by chelation to Gd. The structural and magnetic properties, MR relaxivities, cellular uptake, and application for MRI cell imaging of Gd-CNTs in comparison to the precursor oxidized CNTs are evaluated. Despite the intrinsic T contrast of oxidized CNTs internalized in macrophages, the anchoring of paramagnetic gadolinium onto the nanotube sidewall allows efficient T contrast and MR signal enhancement, which is preserved after CNT internalization by cells. Hence, due to their high dispersibility, Gd-CNTs have the potential to produce positive contrast in vivo following injection into the bloodstream. The uptake of Gd-CNTs in the liver and spleen is assessed using MRI, while rapid renal clearance of extracellular Gd-CNTs is observed, confirming the evidences of other studies using different imaging modalities.
Ajuts:	European Commission 290023
Drets:	Tots els drets reservats.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Carbon nanotubes ; Magnetic resonance imaging ; Contrast agents ; Nanomedicine
Publicat a:	Advanced functional materials, Vol. 24, issue 45 (Dec. 2014) , p. 7173-7186, ISSN 1616-3028

DOI: 10.1002/adfm.201402234

Postprint 40 p, 2.2 MB

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