The effect of green kiwifruit on gas transit and tolerance in healthy humans
Caballero, Noemí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Benslaiman, Bouchra (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ansell, Juliet (Zespri International Limited)
Serra Pueyo, Jordi (Universitat Autònoma de Barcelona. Departament de Medicina)

Fecha:	2020
Resumen:	Green kiwifruit is a fiber-rich fruit that has been shown effective for treatment of constipation. However, fermentation of fibers by colonic bacteria may worsen commonly associated gas-related abdominal symptoms. Aim: To determine the effect of green kiwifruit on transit and tolerance to intestinal gas in humans. In 11 healthy individuals, two gas challenge tests were performed (a) after 2 weeks on a low-flatulogenic diet and daily intake of 2 green kiwifruits and (b) after 2 weeks on a similar diet without intake of kiwifruits. The gas challenge test consisted in continuous infusion of a mixture of gases into the jejunum at 12 mL/min for 2 hours while measuring rectal gas evacuation, abdominal symptoms, and abdominal distension. During the 2 weeks prior to each gas challenge test (on-kiwifruit and off-kiwifruit), the number and consistency of stools, and abdominal symptoms were registered. Intake of kiwifruits was associated with more bowel movements per day (1. 8 ± 0. 1 vs 1. 5 ± 0. 1 off-kiwifruit; P =. 001) and somewhat looser stools (Bristol score 3. 3 ± 0. 2 vs 2. 8 ± 0. 1 off-kiwifruit; P =. 072) without relevant abdominal symptoms. Gas infusion produced similar gas evacuation (1238 ± 254 mL and 1172 ± 290 mL; P =. 4355), perception of symptoms (score 1. 2 ± 0. 2 and 1. 3 ± 0. 3; P =. 2367), and abdominal distension (17 ± 7 mm and 17 ± 6 mm; P =. 4704) while on-kiwifruit or off-kiwifruit. In healthy subjects, green kiwifruit increases stool frequency without relevant effects on intestinal gas transit and tolerance. If confirmed in patients, these fruits may provide a natural and well-tolerated treatment alternative for constipation. In a cross-over, randomized study in healthy subjects, intake of the fibre-rich green kiwifruit increased bowel movements without effects on gas transit and tolerance in response to a gas challenge test. If confirmed in patients, these fruits may provide a natural and well tolerated treatment alternative for constipation.
Nota:	Altres ajuts: This work has been performed as part of the doctoral thesis in medicine of Dr Caballero at the Autonomous University of Barcelona. Dr Serra has received research funds from Salvat, Zespri, and Bayer and acted as consulter/speaker for AB-biotics, Allergan, Bayer, Norgine, Cassen-Recordati, Zespri, and Reckitt Benkiser. Juliet Ansell is enployed by Zespri. Noemi Caballero and Bouchra Benslaiman have nothing to disclouse.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Bloating ; Constipation ; Intestinal gas ; Kiwifruit
Publicado en:	Neurogastroenterology and Motility, Vol. 32 (may 2020) , ISSN 1365-2982

DOI: 10.1111/nmo.13874
PMID: 32431019

8 p, 825.8 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Artículos > Artículos de investigación
Artículos > Artículos publicados