Design of Targeted Nanostructured Coordination Polymers (NCPs) for Cancer Therapy
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química)

Date:	2020
Abstract:	Conventional cancer chemotherapy presents notable drug side effects due to non-selective action of the chemotherapeutics to normal cells. Nanoparticles decorated with receptor-specific ligands on the surface have shown an important role in improving site-selective binding, retention, and drug delivery to the cancer cells. This review summarizes the recent reported achievements using nanostructured coordination polymers (NCPs) with active targeting properties for cancer treatment in vitro and in vivo. Despite the controversy surrounding the effectivity of active targeting nanoparticles, several studies suggest that active targeting nanoparticles notably increase the selectivity and the cytotoxic effect in tumoral cells over the conventional anticancer drugs and non-targeted nanoparticle platform, which enhances drug efficacy and safety. In most cases, the nanocarriers have been endowed with remarkable capabilities such as stimuli-responsive properties, targeting abilities, or the possibility to be monitored by imaging techniques. Unfortunately, the lack of preclinical studies impedes the evaluation of these unique and promising findings for the translation of NCPs into clinical trials.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Coordination polymers ; Nanomedicine ; Cancer therapy ; Drug delivery ; EPR (Enhanced Permeability and Retention effect) ; Tumor-targeting
Published in:	Molecules, Vol. 25, Núm. 15 (August 2020) , art. 3449, ISSN 1420-3049

DOI: 10.3390/molecules25153449
PMID: 32751178

16 p, 1.9 MB

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