Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder : lessons from CNTNAP2, ADGRL3, and PARK2
Dalla Vecchia, Elisa (Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK)
Mortimer, Niall (Hospital Universitari Vall d'Hebron)
Palladino, Viola S. (University Hospital of Frankfurt (Alemanya))
Kittel-Schneider, Sarah (University Hospital of Frankfurt (Alemanya))
Lesch, Klaus-Peter (Department of Translational Neuroscience, School of Mental Health and Neuroscience, Maastricht University, Maastricht)
Reif, Andreas (University Hospital of Frankfurt (Alemanya))
Schenck, Annette (Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands)
Norton, William H. J. (Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK)
Universitat Autònoma de Barcelona

Fecha:	2018
Resumen:	Animal and cellular models are essential tools for all areas of biological research including neuroscience. Model systems can also be used to investigate the pathophysiology of psychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). In this review, we provide a summary of animal and cellular models for three genes linked to ADHD and ASD in human patients - CNTNAP2, ADGRL3, and PARK2. We also highlight the strengths and weaknesses of each model system. By bringing together behavioral and neurobiological data, we demonstrate how a cross-species approach can provide integrated insights into gene function and the pathogenesis of ADHD and ASD. The knowledge gained from transgenic models will be essential to discover and validate new treatment targets for these disorders.
Ayudas:	European Commission 643051
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	ADGRL3 ; Attention-deficit/hyperactivity disorder ; Autism spectrum disorder ; CNTNAP2 ; Cross-species ; Drosophila ; Human induced pluripotent stem cells ; Mouse ; PARK2 ; Zebrafish
Publicado en:	Psychiatric Genetics, Vol. 29 (november 2018) , p. 1-17, ISSN 1473-5873

DOI: 10.1097/YPG.0000000000000211
PMID: 30376466

17 p, 326.4 KB

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