Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases : updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE)
Sharrack, Basil (NIHR Neurosciences Biomedical Research Centre. University of Sheffield)
Saccardi, Riccardo (Careggi University Hospital (Florència, Itàlia))
Alexander, Tobias (Charité-Universitätsmedizin Berlin)
Badoglio, Manuela (EBMT Paris study office. Department of Haematology. Saint Antoine Hospital. INSERM UMR 938. Sorbonne University)
Burman, Joachim (Department of Neuroscience. Uppsala University)
Farge-Bancel, Dominique (EA 3518. Université Denis Diderot)
Greco, Raffaella (IRCCS San Raffaele Scientific Institute (Milà, Itàlia))
Jessop, Helen (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit))
Kazmi, Majid (King's College Hospital NHS Foundation Trust)
Kirgizov, Kirill Igorevich (N.N. Blokhin National Medical Center of Oncology. Institute of Pediatric Oncology and Hematology)
Labopin, Myriam (EBMT Paris study office. Department of Haematology. Saint Antoine Hospital. INSERM UMR 938. Sorbonne University)
Mancardi, Giovanni Luigi (University of Genova and Clinical Scientific Institutes Maugeri. Department of Neuroscience)
Martin, Roland (University Hospital Zurich (Suïssa))
Moore, John (St. Vincent's Health Network. Haematology Department.)
Muraro, Paolo Antonio (Imperial College London)
Rovira Tarrats, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Sormani, Maria Pia (IRCCS Ospedale Policlinico San Martino (Gènova, Itàlia))
Snowden, John A. (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit))
McGrath, Eoin (EBMT Executive Office)
Bambi, Franco (Ospedale Pediatrico. Azienda Ospedaliero Universitaria Meyer (A.O.U. Meyer))
Sanchez-Guijo, Fermin (Instituto de Investigación Biomédica de Salamanca)
Worel, Nina (Medical University of Vienna)
Abinun, Mario (Great North Children's Hospital)
Arnold, Renate (Charité-Universitätsmedizin Berlin)
Brierley, Charlotte (Oxford University Hospitals NHS Foundation Trust)
Castilla-Llorente, Cristina (Unité de transplantation des cellules souches. Département d'Hématologie Gustave Roussy)
Cooper, Nichola (Hammersmith Hospital (Londres))
Daikeler, Thomas D. (University Hospital Basel (Basilea, Suïssa))
Del Papa, Nicoletta (Ospedale Gaetano Pini. Department of Rheumatology)
Finke, Jürgen M. (Department of Medicine-Hematology and Oncology. University of Freiburg)
Hagglund, Hans G. (Department of Hematology. Uppsala University Hospital)
Henes, Jörg Christoph (University Hospital of Tübingen (Alemanya))
Hiepe, Falk (Charité-Universitätsmedizin Berlin)
Kiely, David G. (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit))
Marjanovic, Z. (Department of Haematology. Saint Antoine Hospital)
Martin, Thierry (Strasbourg University Hospital)
Ma, David F. (St. Vincent's Health Network. Haematology Department (Sydney, Austràlia))
Moore, J. (Haematology Department. St. Vincent's Health Network)
Miller, P. (Anthony Nolan Research Institute)
Muraro, P. (Imperial College London)
Oliveira, Maria-Carolina (University of São Paulo. Ribeirão Preto Medical School)
Polushin, A. (First State Pavlov Medical University of Saint Petersburg)
Onida, F. (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Simoes, Belinda (University of São Paulo. Ribeirão Preto Medical School)
Puyade, M. (Centre Hospitalier Universitaire de Poitiers)
Resnick, I. (University Hospital St. Marina)
Rovira Argelagués, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Saif, M. (Manchester Royal Infirmary)
Sakellari, Ioanna (George Papanicolaou General Hospital (Tessalònica, Grècia))
Sharrack, B. (NIHR Neurosciences Biomedical Research Centre. University of Sheffield)
Snarski, E. (Medical University of Warsaw)
Scherer, H. U. (Leiden University Medical Centre. Department of Rheumatology)
Sossa, Claudia (Clinica FOSCAL (Bucaramanga, Colòmbia). Division of Hematology and Hematopoietic Stem Cell Transplantation)
de Vries-Bouwstra, J. (Leiden University Medical Centre. Department of Rheumatology)
Wulffraat, Nico (Wilhelmina Kinderziekenhuis (Utrecht, Països Baixos))
Zaccara, E. (Osp. G. Pini. Department of Rheumatology)
Universitat Autònoma de Barcelona

Fecha:	2020
Resumen:	These updated EBMT guidelines review the clinical evidence, registry activity and mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple sclerosis (MS) and other immune-mediated neurological diseases and provide recommendations for patient selection, transplant technique, follow-up and future development. The major focus is on autologous HSCT (aHSCT), used in MS for over two decades and currently the fastest growing indication for this treatment in Europe, with increasing evidence to support its use in highly active relapsing remitting MS failing to respond to disease modifying therapies. aHSCT may have a potential role in the treatment of the progressive forms of MS with a significant inflammatory component and other immune-mediated neurological diseases, including chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, myasthenia gravis and stiff person syndrome. Allogeneic HSCT should only be considered where potential risks are justified. Compared with other immunomodulatory treatments, HSCT is associated with greater short-term risks and requires close interspeciality collaboration between transplant physicians and neurologists with a special interest in these neurological conditions before, during and after treatment in accredited HSCT centres. Other experimental cell therapies are developmental for these diseases and patients should only be treated on clinical trials.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Peripheral neuropathies ; Bone marrow transplantation
Publicado en:	Bone marrow transplantation, Vol. 55 Núm. 2 (january 2020) , p. 283-306, ISSN 1476-5365

DOI: 10.1038/s41409-019-0684-0
PMID: 31558790

24 p, 2.3 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Instituto de Investigación contra la Leucemia Josep Carreras
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