Buspirone Dose-Response on Facilitating Forelimb Functional Recovery in Cervical Spinal Cord Injured Rats
Ahmed, Rakib Uddin (Department of Biomedical Engineering, , Hung Hom, Kowloon, Hong Kong SAR, China)
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann)
Li, Shuai (Department of Biomedical Engineering, , Hung Hom, Kowloon, Hong Kong SAR, China)
Zheng, Yong-Ping (Department of Biomedical Engineering, , Hung Hom, Kowloon, Hong Kong SAR, China)
Alam, Monzurul (Department of Biomedical Engineering, , Hung Hom, Kowloon, Hong Kong SAR, China)
Universitat Autònoma de Barcelona

Fecha:	2021
Resumen:	Buspirone, widely used as a neuropsychiatric drug, has also shown potentials for motor function recovery of injured spinal cord. However, the optimum dosages of such treatment remain unclear. In this study, we investigated the dose-response of Buspirone treatment on reaching and grasping function in cervical cord injured rats. Seventeen adult Sprague-Dawley rats were trained to reach and grasp sugar pellets before a C4 bilateral dorsal column crush injury. After 1 week post-injury, the rats were divided into 3 groups to receive 1 of 3 different dosages of Buspirone (i. p. , 1 dose/day: 1. 5, n = 5; 2. 5, n = 6 and 3. 5 mg/kg b. w. , n = 6). Forelimb reaching and grip strength test were recorded once per week, within 1 hour of Buspirone administration for 11 weeks post-injury. Different dose groups began to exhibit differences in reaching scores from 4 weeks post-injury. From 4-11 weeks post-injury, the reaching scores were highest in the lowest-dose group rats compared to the other 2 dose groups rats. Average grip strength was also found higher in the lowest-dose rats. Our results demonstrate a significant dose-dependence of Buspirone on the recovery of forelimb motor functions after cervical cord injury with the best performance occurring at the lowest dose tested.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Serotonin ; Cervical cord injury ; Neuromodulation ; Functional rehabilitation
Publicado en:	Dose-Response, Vol. 19 (february 2021) , ISSN 1559-3258

DOI: 10.1177/1559325821998136
PMID: 33716591

10 p, 721.0 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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