Polypropylene and polyvinylidene fluoride transobturator slings for the treatment of female stress urinary incontinence : 1-Year outcomes from a multicentre randomized trial
Sabadell, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Pereda-Núñez, Anna (Hospital General de Granollers)
Ojeda-de-los-Santos, Fernando (Hospital Quirónsalud Barcelona)
Urbaneja, Manuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
González-García, Carmen (Hospital de Viladecans)
Camps-Lloveras, Narcís (Universitat de Barcelona)
Pérez-Plantado, Àngela (Consorci Sanitari del Maresme)
Canet Rodriguez, Judit (Parc Hospitalari Martí i Julià)
Pérez-Espejo, Maria Paz (Hospital General de Riotinto)
Rodríguez-Mias, Nuria (Hospital Universitari Vall d'Hebron)
Sarasa-Castelló, Núria (Hospital General de Granollers)
Palau, Marta (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Montero-Armengol, Anabel (Hospital Universitari Vall d'Hebron)
Salicrú, Sabina (Hospital Universitari Vall d'Hebron)
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Poza, Jose L. (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública

Fecha:	2020
Resumen:	To compare the effectiveness and safety of polypropylene (PP) and polyvinylidene fluoride (PVDF) transobturator tapes (TOT) for the treatment of female stress urinary incontinence (SUI). This is a multicentre randomized trial. Women with SUI or stress-predominant mixed urinary incontinence and scheduled for a TOT procedure were randomized to PP or PVDF slings. The primary outcome was 1-year cure or improvement rate using composite criteria. Complications were also compared. Relationships with outcomes were analyzed using multivariable logistic regressions models. From April 2016 to January 2018 285 participants were randomized. PP and PVDF slings showed similar high cure or improvement rate (91. 0% vs. 95. 6%, p = . 138). Improvement in validated questionnaires was also similar. PVDF slings were associated with a lower rate of de novo urgency incontinence (adjusted odds ratio = 0. 35; 95% confidence interval = 0. 15-0. 80). We found no statistical differences in complications rates, although a higher incidence of long-term pain events were observed in the PP group. The study is underpowered to find differences in specific complications owing to the low number of events. PP and PVDF TOTs are equally effective, although PVDF is associated with fewer cases of de novo urgency incontinence. Further studies are needed to give robust conclusions on safety profiles.
Nota:	Finançament de: Fundación Dexeus Salud de la Mujer; Cardiolink
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	De novo urgency incontinence ; Midurethral sling ; Polypropylene ; Polyvinylidene fluoride ; PVDF ; Sling complications ; Stress urinary incontinence ; Suburethral sling ; Suburethral tape ; Transobturator
Publicado en:	Neurourology and Urodynamics, Vol. 40 (december 2020) , p. 475-482, ISSN 1520-6777

DOI: 10.1002/nau.24586
PMID: 33259073

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