Hybrid metal-phenol nanoparticles with polydopamine-like coating for PET/SPECT/CT imaging
Suárez García, Salvio (Institut Català de Nanociència i Nanotecnologia)
Esposito, Tullio V. F. (University of British Columbia. Faculty of Pharmaceutical Sciences)
Neufeld-Peters, Jenna (University of British Columbia. Faculty of Pharmaceutical Sciences)
Bergamo, Marta (University of Copenhagen. Department of Pharmacy)
Yang, Hua (TRIUMF)
Saatchi, Katayoun (University of British Columbia. Faculty of Pharmaceutical Sciences)
Schaffer, Paul (TRIUMF)
Häfeli, Urs O. (University of Copenhagen. Department of Pharmacy)
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)
Rodríguez-Rodríguez, Cristina (University of British Columbia. Department of Physics and Astronomy)
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química)

Data:	2021
Resum:	The validation of metal-phenolic nanoparticles (MPNs) in preclinical imaging studies represents a growing field of interest due to their versatility in forming predesigned structures with unique properties. Before MPNs can be used in medicine, their pharmacokinetics must be optimized so that accumulation in nontargeted organs is prevented and toxicity is minimized. Here, we report the fabrication of MPNs made of a coordination polymer core that combines In(III), Cu(II), and a mixture of the imidazole 1,4-bis(imidazole-1-ylmethyl)-benzene and the catechol 3,4-dihydroxycinnamic acid ligands. Furthermore, a phenolic-based coating was used as an anchoring platform to attach poly(ethylene glycol) (PEG). The resulting MPNs, with effective hydrodynamic diameters of around 120 nm, could be further derivatized with surface-embedded molecules, such as folic acid, to facilitate in vivo targeting and multifunctionality. The prepared MPNs were evaluated for in vitro plasma stability, cytotoxicity, and cell internalization and found to be biocompatible under physiological conditions. First, biomedical evaluations were then performed by intrinsically incorporating trace amounts of the radioactive metals 111In or 64Cu during the MPN synthesis directly into their polymeric matrix. The resulting particles, which had identical physicochemical properties to their nonradioactive counterparts, were used to perform in vivo single-photon emission computed tomography (SPECT) and positron emission tomography (PET) in tumor-bearing mice. The ability to incorporate multiple metals and radiometals into MPNs illustrates the diverse range of functional nanoparticles that can be prepared with this approach and broadens the scope of these nanoconstructs as multimodal preclinical imaging agents.
Ajuts:	Ministerio de Ciencia e Innovación RTI2018-098027-B-C21 Ministerio de Economía y Competitividad SEV-2017-0706 Ministerio de Economía y Competitividad BES-2015-071492
Nota:	Altres ajuts: the ICN2 is funded by the CERCA programme/Generalitat de Catalunya. The authors acknowledge the support from the Cost ENBA CA15216.
Drets:	Tots els drets reservats.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Nanoscale coordination polymers ; Metal−phenol nanoparticles ; Polydopamine-like coating ; Radioimaging ; SPECT/PET ; 111In-labeling ; 64Cu-labeling
Publicat a:	ACS applied materials & interfaces, Vol. 13, issue 9 (March 2021) , p. 10705-10718, ISSN 1944-8252

DOI: 10.1021/acsami.0c20612

Postprint 28 p, 1.6 MB

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