Spectrum of thyroid dysfunction and dementia : a dose-response meta-analysis of 344,248 individuals from cohort studies
Tang, Xingyao (Beijing Tongren Hospital)
Song, Zhi-Hui (Beijing Tongren Hospital)
Wang, Dawei (Beijing Tongren Hospital)
Yang, Jinkui (Beijing Tongren Hospital)
Augusto Cardoso, Marly (School of Public Health, University of Sao Paulo)
Zhou, Jian-Bo (Beijing Tongren Hospital)
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Thyroid hormone, as a modifiable risk factor for dementia, promotes neurocognitive function and regulates metabolic processes. Various studies have defined different thyroid-stimulating hormone cutoffs, but the safest thyroid-stimulating hormone concentration was absent. A dose-response meta-analysis describing the overall functional relation and identifying exposure intervals associated with a higher or lower disease risk is thus desirable. Therefore, our current analysis was conducted to understand the influence of thyroid dysfunction on dementia risk. We searched PubMed, Embase, and Web of Science before May 1, 2020 for human studies published in English. Studies were considered for inclusion if they used a cohort study design to measure the risk of dementia in different thyroid function status groups, diagnosed thyroid functional status and all-cause dementia, included participants aged >18 years, and provided quantitative measures of data. The analysis contained 17 articles with 344,248 individuals with a 7. 8-year mean follow-up. Ten studies with 329,287 participants indicated that only subclinical hyperthyroidism was associated with an increased risk of dementia. In contrast, subclinical hypothyroidism, clinical hyperthyroidism, and clinical hypothyroidism did not affect dementia. In the dose-response meta-analysis with 46,417 samples from 11 studies, the association of thyroid-stimulating hormone with the risk of dementia exhibited a U-shaped curve. Our study indicated that subclinical hyperthyroidism was associated with the risk of dementia and the thyroid-stimulating hormone concentration at around 1. 55-1. 60 mU/L as the optimum range for the risk of dementia.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Thyroid dysfunction ; Dementia ; Dose-response ; Meta-analysis
Published in:	Endocrine Connections, Vol. 10 (march 2021) , p. 410-421, ISSN 2049-3614

DOI: 10.1530/EC-21-0047
PMID: 33875615

12 p, 1.6 MB

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