Clinical characteristics and outcomes among Brazilian patients with severe acute respiratory syndrome coronavirus 2 infection : An observational retrospective study
Borges do Nascimento, Israel Junior (Medical College of Wisconsin)
Pinto, Luiz Ricardo (Universidade Federal de Minas Gerais)
Alves Fernandes, Valeria (Universidade Federal de Minas Gerais)
Molina Romero, Israel (Hospital Universitari Vall d'Hebron)
de Queiroz Oliveira, João Antonio (Universidade Federal de Minas Gerais)
Soriano Marcolino, Milena (Universidade Federal de Minas Gerais)
Leite, Maria Fátima (Universidade Federal de Minas Gerais)

Data:	2020
Resum:	BACKGROUND: Since February 2020, data on the clinical features of patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and their clinical evolution have been gathered and intensively discussed, especially in countries with dramatic dissemination of this disease. OBJECTIVE: To assess the clinical features of Brazilian patients with SARS-CoV-2 and analyze its local epidemiological features. DESIGN AND SETTING: Observational retrospective study conducted using data from an official electronic platform for recording confirmed SARS-CoV-2 cases. METHODS: We extracted data from patients based in the state of Pernambuco who were registered on the platform of the Center for Strategic Health Surveillance Information, between February 26 and May 25, 2020. Clinical signs/symptoms, case evolution over time, distribution of confirmed, recovered and fatal cases and relationship between age group and gender were assessed. RESULTS: We included 28,854 patients who were positive for SARS-CoV-2 (56. 13% females), of median age 44. 18 years. SARS-CoV-2 infection was most frequent among adults aged 30-39 years. Among cases that progressed to death, the most frequent age range was 70-79 years. Overall, the mortality rate in the cohort was 8. 06%; recovery rate, 30. 7%; and hospital admission rate (up to the end of follow-up), 17. 3%. The average length of time between symptom onset and death was 10. 3 days. The most commonly reported symptoms were coughing (42. 39%), fever (38. 03%) and dyspnea/respiratory distress with oxygen saturation < 95% (30. 98%). CONCLUSION: Coughing, fever and dyspnea/respiratory distress with oxygen saturation < 95% were the commonest symptoms. The case-fatality rate was 8. 06% and the hospitalization rate, 17. 3%.
Nota:	Funding: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) - grant numbers 115293/2019-1 and 162996/2019-5; Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) - grant number APQ-00208-20; and Liver Center at Universidade Federal de Minas Gerais.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca
Matèria:	Severe acute respiratory syndrome coronavirus 2 ; COVID-19 ; SARS-CoV-2 ; Coronavirus infections ; Mandatory reporting ; Public reporting of healthcare data ; Infectious diseases ; Ncov-2019 ; Novel coronavirus ; 2019-nCoV infections ; 2019 novel coronavirus infection
Publicat a:	Sao Paulo Medical Journal, Vol. 138 Núm. 6 (november-desember 2020) , p. 490-497, ISSN 1516-3180

DOI: 10.1590/1516-3180.2020.00365.r1.08092020
PMID: 33263706

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