Outcome of hospitalization for COVID-19 in patients with interstitial lung disease an international multicenter study
Drake, T. M. (Centre for Medical Informatics. The Usher Institute. University of Edinburgh)
Docherty, A. B. (Centre for Medical Informatics. The Usher Institute. University of Edinburgh)
Harrison, E. M. (Centre for Medical Informatics. The Usher Institute. University of Edinburgh)
Quint, J. K. (National Heart and Lung Institute. Imperial College)
Adamali, H. (Academic Respiratory Unit. University of Bristol. Southmead Hospital)
Agnew, Sarah (Liverpool Interstitial Lung Disease Service. Aintree site. Liverpool University Hospitals NHS Foundation Trust)
Babu, S. (Queen Alexandra Hospital (Portsmouth, Regne Unit))
Barber, C. M. (Northern General Hospital)
Barratt, S. (Academic Respiratory Unit. University of Bristol. Southmead Hospital)
Bendstrup, Elisabeth (Aarhus University Hospital (Aarhus, Dinamarca))
Bianchi, S. (Northern General Hospital)
Castillo, Diego (Institut d'Investigació Biomèdica Sant Pau)
Chaudhuri, N. (University of Manchester)
Chua, F. (Royal Brompton and Harefield NHS Foundation Trust)
Coker, R. (Hammersmith Hospital (Londres))
Chang, W. (Nottingham University Hospitals NHS Trust (Regne Unit))
Crawshaw, A. (Birmingham Interstitial Lung Disease Unit. Queen Elizabeth Hospital Birmingham. University Hospitals Birmingham NHS Foundation Trust)
Crowley, L. E. (University of Birmingham)
Dosanjh, D. (Birmingham Interstitial Lung Disease Unit. Queen Elizabeth Hospital Birmingham. University Hospitals Birmingham NHS Foundation Trust)
Fiddler, C. A. (Cambridge University Hospitals NHS Foundation Trust (Regne Unit))
Forrest, I. A. (Department of Respiratory Medicine. Royal Victoria Infirmary. Newcastle upon Tyne Hospitals NHS Foundation Trust)
George, P. M. (Royal Brompton and Harefield NHS Foundation Trust)
Gibbons, M. A. (South West Peninsula ILD Network. Royal Devon & Exeter Foundation NHS Trust)
Groom, K. (Hammersmith Hospital (Londres))
Haney, S. (Northumbria Specialist Emergency Care Hospital. Northumbria Healthcare NHS Foundation Trust)
Hart, S. P. (Respiratory Research Group. Hull York Medical School. Castle Hill Hospital)
Heiden, E. (University Hospital Southampton NHS Foundation Trust (Regne Unit))
Henry, M. (Cork University Hospital)
Ho, L. P. (Oxford Interstitial Lung Disease Service. Oxford University Hospitals NHS Foundation Trust)
Hoyles, R. K. (Oxford Interstitial Lung Disease Service. Oxford University Hospitals NHS Foundation Trust)
Hutchinson, J. (King's Mill Hospital)
Hurley, K. (Beaumont Hospital (Dublín, Irlanda))
Jones, M. (National Institute for Health Research (NIHR). Southampton Biomedical Research Centre & Clinical and Experimental Sciences. University of Southampton)
Jones, S. (Action for Pulmonary Fibrosis. Stuart House)
Kokosi, M. (Guys and St. Thomas' NHS Trust)
Kreuter, M. (Center for Interstitial and Rare Lung Diseases. Pneumology. Thoraxklinik. University of Heidelberg. German Center for Lung Research)
MacKay, L. S. (Northumbria Specialist Emergency Care Hospital. Northumbria Healthcare NHS Foundation Trust)
Mahendran, S. (Kingston Hospital NHS Foundation Trust)
Margaritopoulos, G. (ILD Unit. Manchester University Hospital NHS Foundation Trust. Wythenshawe Hospital)
Molina Molina, Maria (Institut d'Investigació Biomèdica de Bellvitge)
Molyneaux, P. L. (National Heart and Lung Institute. Imperial College)
O'Brien, A. (University Hospital Limerick)
O'Reilly, K. (Department of Respiratory Medicine. Mater Misericordiae University Hospital)
Packham, A. (Birmingham Interstitial Lung Disease Unit. Queen Elizabeth Hospital Birmingham. University Hospitals Birmingham NHS Foundation Trust)
Parfrey, H. (Cambridge University Hospitals NHS Foundation Trust (Regne Unit))
Poletti, V. (Department of Diseases of the Thorax. Morgagni Hospital)
Porter, J. C. (UCL Respiratory. University College London. ILD Service. University College London Hospitals NHS Foundation Trust)
Renzoni, E. (Royal Brompton and Harefield NHS Foundation Trust)
Rivera-Ortega, P. (ILD Unit. Manchester University Hospital NHS Foundation Trust. Wythenshawe Hospital)
Russell, A. M. (Imperial Healthcare NHS Trust. St. Mary's Hospital. The Bays)
Saini, G. (Nottingham University Hospitals NHS Trust (Regne Unit))
Spencer, L. G. (Liverpool Interstitial Lung Disease Service. Aintree site. Liverpool University Hospitals NHS Foundation Trust)
Stella, G. M. (Laboratory of Biochemistry and Genetics. Pneumology Unit. Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo)
Stone, H. (University Hospital North Midlands NHS Trust. Royal Stoke University Hospital)
Sturney, S. (Royal United Hospitals Bath NHS Foundation Trust)
Thickett, D. (University of Birmingham)
Thillai, M. (Cambridge University Hospitals NHS Foundation Trust (Regne Unit))
Wallis, T. (National Institute for Health Research (NIHR). Southampton Biomedical Research Centre & Clinical and Experimental Sciences. University of Southampton)
Ward, K. (National Heart and Lung Institute. Imperial College)
Wells, A. U. (Royal Brompton and Harefield NHS Foundation Trust)
West, A. (Guys and St. Thomas' NHS Trust)
Wickremasinghe, M. (Imperial Healthcare NHS Trust. St. Mary's Hospital. The Bays)
Woodhead, F. (Institute of Lung Health. Interstitial Lung Disease Unit. Glenfield Hospital)
Hearson, G. (NIHR Biomedical Research Centre. Respiratory Research Unit. University of Nottingham)
Howard, L. (NIHR Biomedical Research Centre. Respiratory Research Unit. University of Nottingham)
Baillie, John Kenneth (Intensive Care Unit. Royal Infirmary Edinburgh)
Openshaw, Peter (National Heart and Lung Institute. Imperial College)
Semple, M. G. (Respiratory Medicine. Alder Hey Children's Hospital)
Stewart, I. (NIHR Biomedical Research Centre. Respiratory Research Unit. University of Nottingham)
Jenkins, R. G. (NIHR Biomedical Research Centre. Respiratory Research Unit. University of Nottingham)
Universitat Autònoma de Barcelona

Fecha:	2020
Resumen:	Rationale: The impact of coronavirus disease (COVID-19) on patients with interstitial lung disease (ILD) has not been established. Objectives: To assess outcomes in patients with ILD hospitalized for COVID-19 versus those without ILD in a contemporaneous age-, sex-, and comorbidity-matched population. Methods: An international multicenter audit of patients with a prior diagnosis of ILD admitted to the hospital with COVID-19 between March 1 and May 1, 2020, was undertaken and compared with patients without ILD, obtained from the ISARIC4C (International Severe Acute Respiratory and Emerging Infection Consortium Coronavirus Clinical Characterisation Consortium) cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished idiopathic pulmonary fibrosis from non-idiopathic pulmonary fibrosis ILD and used lung function to determine the greatest risks of death. Measurements and Main Results: Data from 349 patients with ILD across Europe were included, of whom 161 were admitted to the hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching, patients with ILD with COVID-19 had significantly poorer survival (hazard ratio [HR], 1. 60; confidence interval, 1. 17-2. 18; P = 0. 003) than age-, sex-, and comorbidity-matched controls without ILD. Patients with an FVC of,80% had an increased risk of death versus patients with FVC >80% (HR, 1. 72; 1. 05-2. 83). Furthermore, obese patients with ILD had an elevated risk of death (HR, 2. 27; 1. 3923. 71). Conclusions: Patients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity. Stringent precautions should be taken to avoid COVID-19 in patients with ILD.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	COVID-19 ; Idiopathic pulmonary fibrosis ; Interstitial lung disease ; Lung function ; Obesity
Publicado en:	American Journal of Respiratory and Critical Care Medicine, Vol. 202 Núm. 12 (15 2020) , p. 1656-1665, ISSN 1535-4970

DOI: 10.1164/rccm.202007-2794OC
PMID: 33007173

10 p, 772.3 KB

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