COVID-19 in CKD Patients : Lessons from 553 CKD Patients with Biopsy-Proven Kidney Disease
Román, Juan León (Hospital Universitari Vall d'Hebron)
García-Carro, Clara (Hospital Universitari Vall d'Hebron)
Agraz Pamplona, Irene (Hospital Universitari Vall d'Hebron)
Toapanta, Néstor (Hospital Universitari Vall d'Hebron)
Vergara, Ander (Vall d'Hebron Institut de Recerca (VHIR))
Gabaldón, Alejandra (Hospital Universitari Vall d'Hebron)
Torres, Irina B. (Hospital Universitari Vall d'Hebron)
Bury, Roxana (Hospital Universitari Vall d'Hebron)
Baldallo, Cinthia (Hospital Universitari Vall d'Hebron)
Seron, Daniel (Hospital Universitari Vall d'Hebron)
Soler, María José (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Chronic kidney disease (CKD) patients infected with COVID-19 are at risk of serious complications such as hospitalization and death. The prognosis and lethality of COVID-19 infection in patients with established kidney disease has not been widely studied. Data included patients who underwent kidney biopsy at the Vall d'Hebron Hospital between January 2013 and February 2020 with COVID-19 diagnosis during the period from March 1 to May 15, 2020. Thirty-nine (7%) patients were diagnosed with COVID-19 infection. Mean age was 63 ± 15 years and 48. 7% were male. Hypertension was present in 79. 5%, CKD without renal replacement therapy in 76. 9%, and cardiovascular disease in 64. 1%. Nasopharyngeal swab was performed in 26 patients; older (p = 0. 01), hypertensive (p = 0. 005), and immunosuppressed (p = 0. 01) patients, those using RAS-blocking drugs (p = 0. 04), and those with gastrointestinal symptoms (p = 0. 02) were more likely to be tested for CO VID-19. Twenty-two patients required hospitalization and 15. 4% died. In bivariate analysis, mortality was associated with older age (p = 0. 03), cardiovascular disease (p = 0. 05), chronic obstructive pulmonary disease (p = 0. 05), and low hemoglobin levels (p = 0. 006). Adjusted Cox regression showed that low hemoglobin levels at admission had 1. 81 greater risk of mortality. Patients with CO VID-19 infection and kidney disease confirmed by kidney biopsy presented a mortality of 15. 4%. Swab test for COVID-19 was more likely to be performed in older, hypertensive, and immunosuppressed patients, those using RAS-blocking drugs, and those with gastrointestinal symptoms. Low hemoglobin is a risk factor for mortality.
Grants:	Ministerio de Economía y Competitividad RD16/0009/0030
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Coronavirus ; COVID-19 ; Severe acute respiratory syndrome coronavirus 2 ; Chronic kidney disease ; Biopsy-proven kidney disease
Published in:	Kidney & blood pressure research, june 2021, p. 1-8, ISSN 1423-0143

DOI: 10.1159/000515714
PMID: 34098555

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