Plasmonic biosensors for single-molecule biomedical analysis
Mauriz, Elba (Universidad de León. Departamento de Enfermería y Fisioterapia)
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)

Date:	2021
Abstract:	The rapid spread of epidemic diseases (i. e. , coronavirus disease 2019 (COVID-19)) has contributed to focus global attention on the diagnosis of medical conditions by ultrasensitive detection methods. To overcome this challenge, increasing efforts have been driven towards the development of single-molecule analytical platforms. In this context, recent progress in plasmonic biosensing has enabled the design of novel detection strategies capable of targeting individual molecules while evaluating their binding affinity and biological interactions. This review compiles the latest advances in plasmonic technologies for monitoring clinically relevant biomarkers at the single-molecule level. Functional applications are discussed according to plasmonic sensing modes based on either nanoapertures or nanoparticle approaches. A special focus was devoted to new analytical developments involving a wide variety of analytes (e. g. , proteins, living cells, nucleic acids and viruses). The utility of plasmonic-based single-molecule analysis for personalized medicine, considering technological limitations and future prospects, is also overviewed.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Single-molecule analysis ; Biosensors ; Plasmonics ; Nanoparticle ; Nanostructure ; Nucleic acids ; Virus ; Living-cells
Published in:	Biosensors, Vol. 11, issue 4 (April 2021) , art. 123, ISSN 2079-6374

DOI: 10.3390/bios11040123
PMID: 33921010

23 p, 4.8 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles