Multidisciplinary practice guidelines for the diagnosis, genetic counseling and treatment of pheochromocytomas and paragangliomas
García-Carbonero, Rocío (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12))
Matute Teresa, F. (Hospital Clínico San Carlos (Madrid))
Mercader-Cidoncha, E. (Hospital General Universitario Gregorio Marañón)
Mitjavila-Casanovas, M. (Grupo de Trabajo de Endocrino de la SEMNIM, Madrid, Spain)
Robledo, Mercedes (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Tena, I. (Hospital Provincial. Medical Oncology Department)
Álvarez-Escolá, Cristina (Hospital Universitario La Paz (Madrid))
Arístegui, M. (Hospital General Universitario Gregorio Marañón)
Bella-Cueto, Maria Rosa (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Ferrer-Albiach, C. (Consorci Hospitalari Provincial de Castelló)
Hanzu, Felicia A (Institut d'Investigacions Biomèdiques August Pi i Sunyer)

Date:	2021
Abstract:	Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that arise from chromaffin cells of the adrenal medulla and the sympathetic/parasympathetic neural ganglia, respectively. The heterogeneity in its etiology makes PPGL diagnosis and treatment very complex. The aim of this article was to provide practical clinical guidelines for the diagnosis and treatment of PPGLs from a multidisciplinary perspective, with the involvement of the Spanish Societies of Endocrinology and Nutrition (SEEN), Medical Oncology (SEOM), Medical Radiology (SERAM), Nuclear Medicine and Molecular Imaging (SEMNIM), Otorhinolaryngology (SEORL), Pathology (SEAP), Radiation Oncology (SEOR), Surgery (AEC) and the Spanish National Cancer Research Center (CNIO). We will review the following topics: epidemiology; anatomy, pathology and molecular pathways; clinical presentation; hereditary predisposition syndromes and genetic counseling and testing; diagnostic procedures, including biochemical testing and imaging studies; treatment including catecholamine blockade, surgery, radiotherapy and radiometabolic therapy, systemic therapy, local ablative therapy and supportive care. Finally, we will provide follow-up recommendations.
Note:	Altres ajuts: The Spanish Societies of Endocrinology and Nutrition (SEEN), Medical Oncology (SEOM), Medical Radiology (SERAM), Nuclear Medicine and Molecular Imaging (SEMNIM), Otorhinolaryngology (SEORL), Pathology (SEAP), Radiation Oncology (SEOR), and Surgery (AEC) equally funded this project.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Pheochromocytoma ; Paraganglioma ; Diagnosis ; Treatment ; Genetic counseling ; Multidisciplinary ; Guidelines
Published in:	Clinical & Translational Oncology, Vol. 23 (may 2021) , p. 1995-2019, ISSN 1699-3055

DOI: 10.1007/s12094-021-02622-9
PMID: 33959901

25 p, 2.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles