Polyphenols and IUGR Pregnancies : effects of the Antioxidant Hydroxytyrosol on Brain Neurochemistry and Development in a Porcine Model
Yeste, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
García-Contreras, Consolación (Universidad Complutense de Madrid. Facultad de Veterinaria)
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Gonzalez-Bulnes, Antonio (Universidad Complutense de Madrid. Facultad de Veterinaria)
Bassols Teixidó, Anna Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Valent, Daniel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Arroyo, Laura (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Vázquez-Gómez, Marta (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)

Date:	2021
Abstract:	Supplementation of a mother's diet with antioxidants, such as hydroxytyrosol (HTX), has been proposed to ameliorate the adverse phenotypes of fetuses at risk of intrauterine growth restriction. In the present study, sows were treated daily with or without 1. 5 mg of HTX per kilogram of feed from day 35 of pregnancy (at 30% of total gestational period), and individuals were sampled at three different ages: 100-day-old fetuses and 1-month- and 6-month-old piglets. After euthanasia, the brain was removed and the hippocampus, amygdala, and prefrontal cortex were dissected. The profile of the catecholaminergic and serotoninergic neurotransmitters (NTs) was characterized and an immunohistochemical study of the hippocampus was performed. The results indicated that maternal supplementation with HTX during pregnancy affected the NT profile in a brain-area-dependant mode and it modified the process of neuron differentiation in the hippocampal CA1 and GD areas, indicating that cell differentiation occurred more rapidly in the HTX group. These effects were specific to the fetal period, concomitantly with HTX maternal supplementation, since no major differences remained between the control and treated groups in 1-month- and 6-month-old pigs.
Grants:	Ministerio de Economía y Competitividad AGL2013-48121-C3-R Agencia Estatal de Investigación AGL2016-79321-C2-1-R Ministerio de Economía y Competitividad BES-2014-070464 Ministerio de Ciencia e Innovación FPU17/01881 Ministerio de Educación, Cultura y Deporte FPU14/01285
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Hydroxytyrosol ; Neurotransmitters ; Hippocampus ; Neuron differentiation ; Intrauterine growth restriction ; Brain ; Pig ; Oxidative stress
Published in:	Antioxidants, Vol. 10 Núm. 6 (2021) , p. 884, ISSN 2076-3921

DOI: 10.3390/antiox10060884
PMID: 34073097

21 p, 5.0 MB

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