Stable, concentrated, biocompatible, and defect-free graphene dispersions with positive charge
Shin, Yuyoung (University of Manchester. Department of Chemistry)
Vranic, Sandra (University of Manchester. Nanomedicine Lab)
Just-Baringo, Xavier (University of Manchester. Department of Chemistry)
Gali, Sai Manoj (Institut Català de Nanociència i Nanotecnologia)
Kisby, Thomas (University of Manchester. National Graphene Institute)
Chen, Yingxian (University of Manchester. Nanomedicine Lab)
Gkoutzidou, Alexandra (University of Manchester. Department of Materials)
Prestat, Eric (SciTech Daresbury Campus. SuperSTEM Laboratory)
Beljonne, David (Institut Català de Nanociència i Nanotecnologia)
Larrosa, Igor (University of Manchester. Department of Chemistry)
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Casiraghi, Cinzia (University of Manchester. Department of Chemistry)

Date:	2020
Abstract:	The outstanding properties of graphene offer high potential for biomedical applications. In this framework, positively charged nanomaterials show better interactions with the biological environment, hence there is strong interest in the production of positively charged graphene nanosheets. Currently, production of cationic graphene is either time consuming or producing dispersions with poor stability, which strongly limit their use in the biomedical field. In this study, we made a family of new cationic pyrenes, and have used them to successfully produce water-based, highly concentrated, stable, and defect-free graphene dispersions with positive charge. The use of different pyrene derivatives as well as molecular dynamics simulations allowed us to get insights on the nanoscale interactions required to achieve efficient exfoliation and stabilisation. The cationic graphene dispersions show outstanding biocompatibility and cellular uptake as well as exceptional colloidal stability in the biological medium, making this material extremely attractive for biomedical applications.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Biological environments ; Biomedical applications ; Colloidal Stability ; Graphene dispersions ; Graphene nanosheets ; Molecular dynamics simulations ; Nanoscale interactions ; Pyrene derivatives ; Graphite ; Nanostructures ; Water
Published in:	Nanoscale, Vol. 12, Issue 23 (June 2020) , p. 12383-12394, ISSN 2040-3372

DOI: 10.1039/d0nr02689a

12 p, 3.7 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles