Genomic analysis of 18th-century Kazakh individuals and their oral microbiome
White, Anna E. (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
de-Dios, Toni (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Carrión, Pablo (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Bonora, Gian Luca (International Association for Mediterranean and East Studies - ISMEO)
Llovera, Laia (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Cilli, Elisabetta (University of Bologna. Department of Cultural Heritage)
Lizano, Esther (Institut Català de Paleontologia Miquel Crusafont)
Khabdulina, Maral K. (L.N. Gumilev Eurasian National University. K.A. Akishev Institute of Archaeology)
Tleugabulov, Daniyar T. (L.N. Gumilev Eurasian National University. K.A. Akishev Institute of Archaeology)
Olalde, Iñigo (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont)
Balloux, François (University College London. UCL Genetics Institute. Department of Genetics Evolution & Environment)
Pettener, Davide (University of Bologna. Department of Biological, Geological and Environmental Sciences)
van Dorp, Lucy (University College London. UCL Genetics Institute. Department of Genetics Evolution & Environment)
Luiselli, Donata (University of Bologna. Department of Cultural Heritage)
Lalueza-Fox, Carles (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))

Date:	2021
Abstract:	The Asian Central Steppe, consisting of current-day Kazakhstan and Russia, has acted as a highway for major migrations throughout history. Therefore, describing the genetic composition of past populations in Central Asia holds value to understanding human mobility in this pivotal region. In this study, we analyse paleogenomic data generated from five humans from Kuygenzhar, Kazakhstan. These individuals date to the early to mid-18th century, shortly after the Kazakh Khanate was founded, a union of nomadic tribes of Mongol Golden Horde and Turkic origins. Genomic analysis identifies that these individuals are admixed with varying proportions of East Asian ancestry, indicating a recent admixture event from East Asia. The high amounts of DNA from the anaerobic Gram-negative bacteria Tannerella forsythia, a periodontal pathogen, recovered from their teeth suggest they may have suffered from periodontitis disease. Genomic analysis of this bacterium identified recently evolved virulence and glycosylation genes including the presence of antibiotic resistance genes predating the antibiotic era. This study provides an integrated analysis of individuals with a diet mostly based on meat (mainly horse and lamb), milk, and dairy products and their oral microbiome.
Grants:	Ministerio de Ciencia e Innovación PGC2018-0955931-B-100 European Commission 864203 Ministerio de Economía y Competitividad BFU2017-86471-P Agencia Estatal de Investigación CEX2018-000792-M Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-880
Note:	Altres ajuts: CERCA Programme/Generalitat de Catalunya
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Paleogenomics ; Ancient pathogens ; Central Asian steppe ; Red complex ; Bacteria
Published in:	Biology, Vol. 10, Issue 12 (December 2021) , art. 1324, ISSN 2079-7737

DOI: 10.3390/biology10121324
PMID: 34943238

22 p, 2.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Institut Català de Paleontologia Miquel Crusafont (ICP)
Articles > Research articles
Articles > Published articles