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Página principal > Artículos > Artículos publicados > The genetic impact of an Ebola outbreak on a wild gorilla population |
Fecha: | 2021 |
Resumen: | Background: Numerous Ebola virus outbreaks have occurred in Equatorial Africa over the past decades. Besides human fatalities, gorillas and chimpanzees have also succumbed to the fatal virus. The 2004 outbreak at the Odzala-Kokoua National Park (Republic of Congo) alone caused a severe decline in the resident western lowland gorilla (Gorilla gorilla gorilla) population, with a 95% mortality rate. Here, we explore the immediate genetic impact of the Ebola outbreak in the western lowland gorilla population. Results: Associations with survivorship were evaluated by utilizing DNA obtained from fecal samples from 16 gorilla individuals declared missing after the outbreak (non-survivors) and 15 individuals observed before and after the epidemic (survivors). We used a target enrichment approach to capture the sequences of 123 genes previously associated with immunology and Ebola virus resistance and additionally analyzed the gut microbiome which could influence the survival after an infection. Our results indicate no changes in the population genetic diversity before and after the Ebola outbreak, and no significant differences in microbial community composition between survivors and non-survivors. However, and despite the low power for an association analysis, we do detect six nominally significant missense mutations in four genes that might be candidate variants associated with an increased chance of survival. Conclusion: This study offers the first insight to the genetics of a wild great ape population before and after an Ebola outbreak using target capture experiments from fecal samples, and presents a list of candidate loci that may have facilitated their survival. |
Ayudas: | European Commission 676154 Ministerio de Economía y Competitividad BFU2015-68649-P European Commission 864203 Agencia Estatal de Investigación BFU2017-86471-P Agencia Estatal de Investigación CEX2018-000792-M Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-880 Agencia Estatal de Investigación PGC2018-101927-BI00 |
Nota: | Altres ajuts: "la Caixa" PhD fellowship code LCF/BQ/DE15/10360006 and "la Caixa" Foundation (ID 100010434), fellowship code LCF/BQ/PR19/11700002 |
Nota: | Altres ajuts: CERCA Programme/Generalitat de Catalunya |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Ebola ; Gorilla ; Non-invasive samples ; Candidate genes |
Publicado en: | BMC genomics, Vol. 22 (October 2021) , art. 735, ISSN 1471-2164 |
12 p, 1.3 MB |