Aging Impairs Reverse Remodeling and Recovery of Ventricular Function after Isoproterenol-Induced Cardiomyopathy
Yáñez-Bisbe, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Garcia-Elias, Anna (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Tajes, Marta (Institut d'Investigació Biomèdica de Bellvitge)
Almendros, Isaac (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Rodríguez-Sinovas, Antonio (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Inserte, Javier (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Ruiz Meana, Marisol (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Farré, Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Farré, Núria (Universitat Autònoma de Barcelona. Departament de Medicina)
Benito, Begoña (Universitat Autònoma de Barcelona. Departament de Medicina)

Data:	2021
Resum:	Information about heart failure with reduced ejection fraction (HFrEF) in women and the potential effects of aging in the female heart is scarce. We investigated the vulnerability to develop HFrEF in female elderly mice compared to young animals, as well as potential differences in reverse remodeling. First, HF was induced by isoproterenol infusion (30 mg/kg/day, 28 days) in young (10-week-old) and elderly (22-month-old) female mice. In a second set of animals, mice underwent isoproterenol infusion followed by no treatment during 28 additional days. Cardiac remodeling was assessed by echocardiography, histology and gene expression of collagen-I and collagen-III. Following isoproterenol infusion, elderly mice developed similar HFrEF features compared to young animals, except for greater cell hypertrophy and tissue fibrosis. After beta-adrenergic withdrawal, young female mice experienced complete reversal of the HFrEF phenotype. Conversely, reversed remodeling was impaired in elderly animals, with no significant recovery of LV ejection fraction, cardiomyocyte hypertrophy and collagen deposition. In conclusion, chronic isoproterenol infusion is a valid HF model for elderly and young female mice and induces a similar HF phenotype in both. Elderly animals, unlike young, show impaired reverse remodeling, with persistent tissue fibrosis and cardiac dysfunction even after beta-adrenergic withdrawal.
Ajuts:	Ministerio de Economía y Competitividad PI16/00619
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Heart failure ; HFrEF ; Ageing ; Cardiac remodeling ; Ventricular dysfunction ; Reverse remodeling ; Female animals
Publicat a:	International journal of molecular sciences, Vol. 23 (december 2021) , ISSN 1422-0067

DOI: 10.3390/ijms23010174
PMID: 35008601

12 p, 2.2 MB

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