Prognostic Value of the Acute-to-Chronic Glycemic Ratio at Admission in Heart Failure : A Prospective Study
Carrera, Mª José (Universitat Autònoma de Barcelona. Departament de Medicina)
Moliner, Pedro ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat de Barcelona. Departament de Ciències Clíniques)
Llauradó, Gemma ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Departament de Medicina)
Enjuanes, Cristina ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat de Barcelona. Departament de Ciències Clíniques)
Conangla, Laura ![Identificador ORCID](/img/uab/orcid.ico)
(Institut Català de la Salut)
Chillaron, Juan Jose ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Departament de Medicina)
Ballesta Purroy, Sílvia
(Institut Hospital del Mar d'Investigacions Mèdiques)
Climent, Elisenda
(Universitat Autònoma de Barcelona. Departament de Medicina)
Comín-Colet, Josep
(Universitat de Barcelona. Departament de Ciències Clíniques)
Flores-Le Roux, Juana Antonia
(Universitat Autònoma de Barcelona. Departament de Medicina)
Data: |
2021 |
Resum: |
Acute hyperglycemia has been associated with worse prognosis in patients hospitalized for heart failure (HF). Nevertheless, studies evaluating the impact of glycemic control on long-term prognosis have shown conflicting results. Our aim was to assess the relationship between acute-to-chronic (A/C) glycemic ratio and 4-year mortality in a cohort of subjects hospitalized for acute HF. A total of 1062 subjects were consecutively included. We measured glycaemia at admission and estimated average chronic glucose levels and the A/C glycemic ratio were calculated. Subjects were stratified into groups according to the A/C glycemic ratio tertiles. The primary endpoint was 4-year mortality. Subjects with diabetes had higher risk for mortality compared to those without (HR 1. 35 [95% CI: 1. 10-1. 65]; p = 0. 004). A U-shape curve association was found between glucose at admission and mortality, with a HR of 1. 60 [95% CI: 1. 22-2. 11]; p = 0. 001, and a HR of 1. 29 [95% CI: 0. 97-1. 70]; p = 0. 078 for the first and the third tertile, respectively, in subjects with diabetes. Additionally, the A/C glycemic ratio was negatively associated with mortality (HR 0. 76 [95% CI: 0. 58-0. 99]; p = 0. 046 and HR 0. 68 [95% CI: 0. 52-0. 89]; p = 0. 005 for the second and third tertile, respectively). In multivariable analysis, the A/C glycemic ratio remained an independent predictor. In conclusion, in subjects hospitalized for acute HF, the A/C glycemic ratio is significantly associated with mortality, improving the ability to predict mortality compared with glucose levels at admission or average chronic glucose concentrations, especially in subjects with diabetes. |
Drets: |
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Llengua: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Matèria: |
Heart failure ;
Diabetes mellitus ;
Chronic complications |
Publicat a: |
Journal of clinical medicine, Vol. 11 (2022) , ISSN 2077-0383 |
DOI: 10.3390/jcm11010006
PMID: 35011747
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