Impact of a Novel Strategy for Critical Values Communication for the Management of Patients Treated with Clozapine
Cano-Corres, Ruth (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Acebillo, Siddarta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Barreda, Francesc Campos (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Palao, Diego (Centro de Investigación Biomédica en Red de Salud Mental)
Berlanga Escalera, Eugenio (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Clozapine is an antipsychotic drug used to treat resistant schizophrenia and other disorders. Based on the actual Spanish legislation, patients treated with clozapine must undergo periodical haematological examinations and treatment should be reviewed when the haemogram shows either a leukocyte count of ≤ 3500/mm 3 or neutrophil count < 2000/mm 3. An automatic notification system has been developed to optimize patient management and it's utility was assessed following the implementation of the new system. When clozapine (CLO) laboratory test request was made, a reflex complete blood count test was also done. An automatic e-mail was sent by the laboratory information system to the physician when a CLO was ordered and low leukocyte or neutrophil counts were detected, or when a patient with an ordered CLO test did not attend the laboratory for blood drawing. For patients with haemogram alterations, the time to take clinical action was significantly decreased from 23 to 7 days (p = 0. 02). Moreover, the adherence to Spanish Agency of Drugs and Sanitary Devices recommendations significantly increased from 45% to 76% (p = 0. 02). For not attending patients, the days out of control decreased from 29 to 12 days, although it was not statistically significant (p = 0. 06). This strategy has allowed the compliance of legal requirements, the improvement of patient safety, and the optimisation of clinical and laboratory procedures.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Clozapine ; E-mail ; Haemogram alterations ; Patients' safety ; Values communication
Published in:	EJIFCC, Vol. 32 (december 2021) , p. 458-466, ISSN 1650-3414

PMID: 35046764

9 p, 524.0 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles