Health economic impact of first-pass success among patients with acute ischemic stroke treated with mechanical thrombectomy : a United States and European perspective
Zaidat, Osama (Mercy Saint Vincent Medical Center)
Ribo, Marc (Universitat Autònoma de Barcelona. Departament de Medicina)
Mattle, Heinrich Paul (University of Bern)
Saver, Jeffrey L.. (UCLA)
Bozorgchami, Hormozd (Oregon Health and Science University)
Yoo, Albert J. (Texas Stroke Institute)
Ehm, Alexandra (Johnson & Johnson Medical GmbH)
Kottenmeier, Emilie (Cerenovus, Johnson & Johnson)
Cameron, Heather L. (EVERSANA)
Qadeer, Rana A. (EVERSANA)
Andersson, Tommy (Karolinska University Hospital and Karolinska Institutet (Suècia))

Data:	2020
Resum:	First-pass effect (FPE), restoring complete or near complete reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI) 2c-3) in a single pass, is an independent predictor for good functional outcomes in the endovascular treatment of acute ischemic stroke. The economic implications of achieving FPE have not been assessed. To assess the economic impact of achieving complete or near complete reperfusion after the first pass. Post hoc analyses were conducted using ARISE II study data. The target population consisted of patients in whom mTICI 2c-3 was achieved, stratified into two groups: (1) mTICI 2c-3 achieved after the first pass (FPE group) or (2) after multiple passes (non-FPE group). Baseline characteristics, clinical outcomes, and healthcare resource use were compared between groups. Costs from peer-reviewed literature were applied to assess cost consequences from the perspectives of the United States (USA), France, Germany, Italy, Spain, Sweden, and United Kingdom (UK). Among patients who achieved mTICI 2c-3 (n=172), FPE was achieved in 53% (n=91). A higher proportion of patients in the FPE group reached good functional outcomes (90-day modified Rankin Scale score 0-2 80. 46% vs 61. 04%, p<0. 01). The patients in the FPE group had a shorter mean length of stay (6. 10 vs 9. 48 days, p<0. 01) and required only a single stent retriever, whereas 35% of patients in the non-FPE group required at least one additional device. Driven by improvement in clinical outcomes, the FPE group had lower procedural/hospitalization-related (24-33% reduction) and annual care (11-27% reduction) costs across all countries. FPE resulted in improved clinical outcomes, translating into lower healthcare resource use and lower estimated costs.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Stroke ; Thrombectomy ; Economics
Publicat a:	Journal of Neurointerventional Surgery, Vol. 13 (december 2020) , p. 1117-1123, ISSN 1759-8486

DOI: 10.1136/neurintsurg-2020-016930
PMID: 33443119

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