Effects of virgin olive oil and phenol-enriched virgin olive oils on lipoprotein atherogenicity
Farràs Mañé, Marta (Institut d'Investigació Biomèdica Sant Pau)
Canyelles, Marina (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Fitó, Montserrat (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Escolà-Gil, Joan Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)

Fecha:	2020
Resumen:	The atherogenicity of low-density lipoprotein (LDL) and triglyceride-rich lipoproteins (TRLs) may be more significant than LDL cholesterol levels. Clinical trials which have led to increased high-density lipoprotein (HDL) cholesterol have not always seen reductions in cardiovascular disease (CVD). Furthermore, genetic variants predisposing individuals to high HDL cholesterol are not associated with a lower risk of suffering a coronary event, and therefore HDL functionality is considered to be the most relevant aspect. Virgin olive oil (VOO) is thought to play a protective role against CVD. This review describes the effects of VOO and phenol-enriched VOOs on lipoprotein atherogenicity and HDL atheroprotective properties. The studies have demonstrated a decrease in LDL atherogenicity and an increase in the HDL-mediated macrophage cholesterol efflux capacity, HDL antioxidant activity, and HDL anti-inflammatory characteristics after various VOO interventions. Moreover, the expression of cholesterol efflux-related genes was enhanced after exposure to phenol-enriched VOOs in both post-prandial and sustained trials. Improvements in HDL antioxidant properties were also observed after VOO and phenol-enriched VOO interventions. Furthermore, some studies have demonstrated improved characteristics of TRL atherogenicity under postprandial conditions after VOO intake. Large-scale, long-term randomized clinical trials, and Mendelian analyses which assess the lipoprotein state and properties, are required to confirm these results.
Ayudas:	Instituto de Salud Carlos III FIS19-00136 Instituto de Salud Carlos III FISP18/00020 Instituto de Salud Carlos III FIS16-00139 Instituto de Salud Carlos III FIS15-00047
Nota:	Altres ajuts: Marató TV3 201512.31 (to M.Fi.), and Sara Borrell contract CD17/00233 (to M.Fa). CIBERDEM and CIBEROBN are Instituto de Salud Carlos III projects.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Triglyceride-rich lipoprotein ; Chylomicrons ; High density lipoprotein ; Low density lipoprotein ; Virgin olive oil
Publicado en:	Nutrients, Vol. 12, issue 3 (March 2020) , art. 601, ISSN 2072-6643

DOI: 10.3390/nu12030601
PMID: 32110861

26 p, 568.6 KB

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