Mycobacteria-Based Vaccines as Immunotherapy for Non-urological Cancers
Noguera-Ortega, Estela (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Guallar Garrido, Sandra (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Date: |
2020 |
Abstract: |
The arsenal against different types of cancers has increased impressively in the last decade. The detailed knowledge of the tumor microenvironment enables it to be manipulated in order to help the immune system fight against tumor cells by using specific checkpoint inhibitors, cell-based treatments, targeted antibodies, and immune stimulants. In fact, it is widely known that the first immunotherapeutic tools as immune stimulants for cancer treatment were bacteria and still are; specifically, the use of Mycobacterium bovis bacillus Calmette-Guérin (BCG) continues to be the treatment of choice for preventing cancer recurrence and progression in non-invasive bladder cancer. BCG and also other mycobacteria or their components are currently under study for the immunotherapeutic treatment of different malignancies. This review focuses on the preclinical and clinical assays using mycobacteria to treat non-urological cancers, providing a wide knowledge of the beneficial applications of these microorganisms to manipulate the tumor microenvironment aiming at tumor clearance. |
Grants: |
Agencia Estatal de Investigación RTI2018-098777-B-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-229
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Rights: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Language: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Subject: |
BCG ;
Non-tuberculous mycobacteria ;
Adjuvant ;
Immunotherapy ;
Mycobacteria antigens |
Published in: |
Cancers, Vol. 12, Issue 7 (July 2020) , art. 1802, ISSN 2072-6694 |
DOI: 10.3390/cancers12071802
PMID: 32635668
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Record created 2022-02-07, last modified 2022-10-20