Alcohol Induced Depression : Clinical, Biological and Genetic Features
Farré Martínez, Adriana (Institut Hospital del Mar d'Investigacions Mèdiques)
Tirado, Judit (Institut Hospital del Mar d'Investigacions Mèdiques)
Spataro, Nino (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Alías Ferri, María (Institut Hospital del Mar d'Investigacions Mèdiques)
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Fonseca, Francina 1972- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)

Fecha:	2020
Resumen:	Background: In clinical practice, there is the need to have clinical and biological markers to identify induced depression. The objective was to investigate clinical, biological and genetic differences between Primary Major Depression (Primary MD) and Alcohol Induced MD (AI-MD). Methods: Patients, of both genders, were recruited from psychiatric hospitalisation units. The PRISM instrument was used to establish the diagnoses. Data on socio-demographic/family history, clinical scales for depression, anxiety, personality and stressful life events were recorded. A blood test was performed analysing biochemical parameters and a Genome Wide Association Study (GWAS) to identify genetic markers associated with AI-MD. Results: A total of 80 patients were included (47 Primary MD and 33 AI-MD). The AI-MD group presented more medical comorbidities and less family history of depression. There were differences in traumatic life events, with higher scores in the AI-MD (14. 21 ± 11. 35 vs. 9. 30 ± 7. 38; p = 0. 021). DSM-5 criteria were different between groups with higher prevalence of weight changes and less anhedonia, difficulties in concentration and suicidal thoughts in the AI-MD. None of the genetic variants reached significance beyond multiple testing thresholds; however, some suggestive variants were observed. Conclusions: This study has found clinical and biological features that may help physicians to identify AI-MD and improve its therapeutic approach.
Ayudas:	European Commission 634143 Ministerio de Economía y Competitividad RD12/0028/0009 Ministerio de Economía y Competitividad RD16/0017/0010
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Primary major depression ; Alcohol use disorder ; Alcohol induced major depression ; Biomarkers ; Comorbidity ; Clinical characteristics ; GWAS
Publicado en:	Journal of clinical medicine, Vol. 9 (august 2020) , ISSN 2077-0383

DOI: 10.3390/jcm9082668
PMID: 32824737

17 p, 1005.0 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Instituto de Investigación e Innovación Parc Taulí (I3PT)
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